СВЯЗЬ ПОЛИМОРФИЗМА МАТРИЧНЫХ МЕТАЛЛОПРОТЕИНАЗ-З С АРТЕРИАЛЬНОЙ ЖЁСТКОСТЬЮ У ПАЦИЕНТОВ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА

At present, the genetic basis of hereditary disorders has been determined, which are manifested by a change in the metabolism of matrix proteins, that leads to an increase in arterial wall stiffness. Matrix metalloproteinases (MMP) play a key role in the physiological remodeling of tissues and MMP-3 is particularly important for the remodeling of the arterial wall, as it potentially contributes to the development of structural changes in the vessel wall due to the degradation of extracellular matrix proteins, especially in patients with coronary atherosclerosis. Purpose of the study: study of polymorphism of MMP-3 5A and 6A alleles in patients with ischemic heart disease (IHD) and their effect on arterial wall stiffness. Material and methods. The study was conducted on the basis of the laboratory of ischemic heart disease of the Republican Specialized Scientific Medical Center for Cardiology for the period 2015–2018 among 100 patients (51 men and 49 women) aged 55 years and older with stable ischemic heart disease. The parameters of central hemodynamics (HD) and arterial wall stiffness were estimated using the automated system of the SphygmoCor (AtCor MEDICAL Pty Ltd, Australia). DNA isolation was made from whole blood using the «DiatomTM DNA Prep 200: Isogene RUS» kit. Results of the study. When evaluating the parameters of the central HD, patients had elevated values of cSBD, cPP, AIx and AA. However, the differences were significant in terms of such parameters as cSBP (p = 0,007), cPP (p = 0,042) between carriers and non-carriers of the 5A allele, respectively. The values of PWV and АIx corresponded to increased, regardless of the type of carriage of the genotype MMP-3. A significant difference was noted in PWV both in the general cohort (p = 0,0015), and when comparing this indicator in carriers and non-carriers 5A allele in men (p = 0,0017) and women (p = 0,0013). Conclusion. In our study, the data obtained indicate that variations of the MMP gene are strong potential genetic factors for IHD and increased arterial wall stiffness, the severity of which is maximal at 6A/6A MMP-3 genotype (non-carriers of 5A allele). Further study of this hypothesis requires additional genetic epidemiological studies with a large number of patients.