ЮҚОРИ ХАВФИ БОР ГИПЕРТОНИЯЛИ БЕМОРЛАРДА БУЙРАК ШИКАСТЛАНИШИНИНГ ЮРАК-ҚОН ТОМИР РЕМОДЕЛЛАНИШИГА ТАЪСИРИ

The aim of the study was to identify the effect of chronic kidney disease (CKD) on the development of cardiovascular remodeling in high-risk patients with arterial hypertension (AH). Material and research methods. The study included 100 high-risk hypertensive patients undergoing treatment at the RSSPMCC in the hypertension department, the average age of patients was 62.2 ± 9.79 years, 51 men and 49 women. All patients were examined by “Protocol to examination of high risk AH” and were performed ECG, Echo with Doppler echocardiography, ultrasound of brachiocephalic arteries, ABPM, biochemical blood test, urine albumin level. According to the estimated glomerular filtration rate (eGFR) the patients were divided into 2 groups: first group patients with eGFR < 60-ml/min/1.73 m2 (n = 43), second group with eGFR >60-ml/min/1.73 m2 (n = 57). On the 1st group patients were diagnosed with CKD 3A (n = 35) and 3B (n = 8) stages. Results. The age and duration of AH in patients in 1st group were significantly greater than in 2nd one. Although systolic and diastolic blood pressure did not differ according to office and ABPM measurements, the pulse pressure in patients of the 1st g roup w as h igher t han i n 2 nd one. Patients of the 1st group showed a significantly high level of uric acid, microalbuminuria, the severity of left ventricular hypertrophy and the thickness of the intima-media of the common carotid artery compared with patients of the 2nd group. Conclusion. Chronic kidney disease in high-risk hypertensive patients, associated with the duration of hypertension, age, pulse pressure, and hyperuricemia, is a predictor of cardiovascular remodeling, nephrosclerosis, and cardiovascular complications