ОСОБЕННОСТИ РЕМОДЕЛИРОВАНИЯ СЕРДЦА У БОЛЬНЫХ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТЬЮ С СОХРАНЕННОЙ И ПРОМЕЖУТОЧНОЙ ФРАКЦИЕЙ ВЫБРОСА

Objective: An assessment of clinical and functional characteristics at CHF patients with mild and preserved LVEF, also as the effect of Valsartan on the parameters of intraventricular hemodynamics. Materials and methods: The study included 32 patients (19 men and 13 women) who applied to the clinic of the Khorezm branch of the Republic Specialized Center of Cardiology. Patients, according to the initial echocardiography, were divided into 2 groups: patients with mild EF (18 patients) and preserved EF (14 patients). Standard therapy in both groups of patients included valsartan at an average dose of 80 mg per day, beta-blockers if necessary to reduce heart rate, antagonists of mineralocorticoid receptors, statins and antiplatelet agents, if necessary loop diuretics. Results: it was revealed that despite the differences in the EF indicators, the compared groups did not differ in the frequency of complaints. Valsartan, as part of traditional therapy, improved the clinical course of heart failure and hemodynamic parameters, while a more pronounced dynamics was observed in the group with intermediate LVEF. Conclusion: the study was devoted to the features of heart remodeling in patients with a preserved and mild ejection fraction. Despite the differences in hemodynamics, the clinical symptoms in these patients are largely similar, which requires the early appointment of pathogenetic treatment. The appointment of valsartan as part of standard therapy contributed to the clinical improvement of the course of heart failure in both groups, and in the group with mild EF to the improvement of hemodynamic parameters.