ВЗГЛЯД НА ПРОБЛЕМУ ВЗАИМОСВЯЗИ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТИ И САХАРНОГО ДИАБЕТА 2: ДОСТИЖЕНИЯ И ПЕРСПЕКТИВЫ

Diabetes mellitus and heart failure are two multifaceted phenomena characterized by high morbidity and mortality. Early epidemiological and prospective studies have shown the frequent coexistence of both conditions. It is important to note that diabetes mellitus can accelerate or exacerbate heart failure due to the accumulation of advanced glycation end products, oxidative stress, impaired inflammatory status, breakdown of intracellular calcium, changes in miRNA expression, not to mention the progression of atherosclerosis and coronary heart disease. Heart failure also disrupts glucose metabolism through lesser known mechanisms. Experimental evidence suggests that different mechanisms contribute to the dysfunction of systolic and diastolic function in diabetic patients, and there is growing recognition that these patients develop heart failure regardless of the presence of coronary artery disease or associated risk factors. Special attention should be paid to treatment, since adverse interactions are often observed between the two diseases, therefore, new hypoglycemic drugs are being actively studied for the treatment of this category of patients. In addition, current clinical data have demonstrated that treatment with modern antihyperglycemic drugs reduces the number of hospitalizations for heart failure in patients with type 2 diabetes and a high risk of cardiovascular disease