СОВРЕМЕННЫЕ ПОДХОДЫ К ДИАГНОСТИКЕ И ЛЕЧЕНИЮ СТАБИЛЬНОЙ СТЕНОКАРДИИ (ХРОНИЧЕСКИЙ КОРОНАРНЫЙ СИНДРОМ (ХКС)

Chronic stable angina pectoris pathophysiologically can be divided into three main categories: stable, vasospastic and microvascular. But, these various pathophysiological conditions that cause myocardial ischemia are accompanied by a symptom: chronic stable angina pectoris. Stable angina pectoris occurs when myocardial ischemia is caused by a fixed atherosclerotic narrowing of one or more epicardial coronary arteries. In some circumstances, angina pectoris is associated with coronary spasm and metabolic disorders. Treatment of chronic stable angina pectoris includes lifestyle changes, control of risk factors for coronary heart disease (CHD), as well as invasive and non – Invasive intervention. Pharmacological therapy has two main objectives: firstly, relief of symptoms with increased exercise tolerance with improved quality of life; and secondly, the prevention of cardiovascular events, mainly myocardial infarction and death. This article discusses only drug therapy that helps to reduce the symptoms of chronic stable angina pectoris. The combination of two or more anti – Ischemic drugs with additive or synergistic effects is often necessary to effectively control symptoms. These combinations should also be adapted to the type of chronic stable angina and the individual patient.