Количественные и качественные характеристики тромбоцитов крови в зависимости от психосоциальных факторов кардиоваскулярного риска

Purpose: to assess the influence of psychosocial factors of cardiovascular risk on the morphological characteristics of blood platelets in patients with coronary heart disease (CHD). Material and methods: 112 persons were examined, including 84 patients with coronary artery disease, stable angina pectoris (SAP) FC II–III. The level of psychoemotional status was assessed using the hospital scale of anxiety and depression HADS. Personality type D was assessed using the DS14 questionnaire. The study of the phenotype of platelets in the blood was carried out on a high-tech hemoanalyzer series XN 1000, using flow cytometry. Results: In group I patients with anxiety-depressive symptoms (ADS), the mean platelet count (PLT) was 312,1 ± 17,17×109/L, and in type D patients, the PLT value averaged 316,7 ± 17,54 × 109/L, which significantly prevailed over the average PLT – 220,4 ± 10,48 × 109/L in the comparison group without ADS (p < 0,001). The mean value of the platelet distribution width (PDW) was significantly higher in group I patients on average 17,0 ± 0,94 fL versus 13,6 ± 0,76 fL compared with patients in group II (p < 0,05). The indicator of the mean platelet volume (MPV) in patients of group I against the background of anxiety and depression statistically significantly exceeded the MPV values, which averaged 11,3 ± 0,42, in contrast to the indicators of the comparison and control group: 9,7 ± 0,23 and 8,7 ± 0,28 fL, respectively (p < 0,001). Conclusion: Increased functional activity of blood platelets in patients with coronary artery disease is caused by the influence of ADS associated with personality type D.