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Some Aspects Of Pathogenesis Of Parodontal Pathology In Chronic Kidney Disease

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The relationship between somatic pathology and the state of the oral cavity caused by impaired metabolism, hemodynamics, microcirculation, immunological and neuro regulatory changes. Immunological changes in generalized parodontitis are characterized by disturbances in the interaction of factors of nonspecific resistance of the organism, inhibition of cellular and humoral immunity, as well as the suppression of relatively autonomous system of local immunity with an imbalance indicators cytokines. There is a morphological and immunological conjugate of pathological processes in the 18 tissues of the kidneys and parodontal patients with chronic kidney disease who manifest lymphocytic infiltration, fibrosis, vascular lesions of the microvasculature. It is found that the levels of IL-6 and IL-8 in saliva significantly correlated with the development of diseases of the oral mucosa in patients with chronic kidney disease. Renal replacement therapy may affect the state of parodontal tissues, including gingival hyperplasia with immunosuppression after kidney transplantation, an increase of microbial contamination, gingivitis, tartar, and a possible increase in the prevalence and severity of periodontal destructive processes. Furthermore, undiagnosed parodontitis may have a significant aggravating effects on the treatment of patients with CKD in the terminal stage.

AUTHORS

J.Abduwakilov

J.Rizaev

A.Gadaev

Tags

# chronic kidney disease# цитокинлар# cytokines# хроническая болезнь почек# пародонт# parodont# цитокины.# сурункали буйраклар касаллиги

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