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Research of association of single nucleotide polymorphisms gene GLUT9, URAT1 with coronary heart disease in the Uzbek population

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Биомедицина ва амалиёт журнали

Биомедицина ва амалиёт журнали

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ARTICLE ANNOTATION

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The purpose of this study was to investigate the effect of SNP genes GLUT9, URAT1 in predisposition to CHD in the Uzbek population. The study included 106 patients with coronary heart disease and 64 individuals in the control group. Polymorphism GLUT9 (rs52448471), URAT1 (rs3825016) were genotyped using the polymerase chain reaction protocol with the definition of restriction fragment length polymorphism. Statistical analysis revealed a significant allelic variant, the T/T genotype of the glucose transporter gene GLUT9, which is associated with unstable forms of СHD. The T/T variant of the gene URAT1 was associated with a stable course of the disease. The research results showed the importance of the polymorphic variant of the genes URAT1 and GLUT9 in the formation of the genetic structure of the predisposition to coronary heart disease in the Uzbek population

AUTHORS

D.Togaev

F.Kadirova

SH.Ziyadullaev

E.Tashkenbaeva

Tags

# юрак ишемик касаллиги# ишемическая болезнь сердца# однонуклеотидный полиморфизм# GLUT9# URAT1# Coronary heart disease# single nucleotide polymorphism# ягона нуклеотид полиморфизм

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Article Identifiers

ROI:

https://eroi.uz/11.0037/A1119-0196

DOI:

Not Available

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