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METABOLIC PREDICTORS OF ANXIETY AND DEPRESSION IN PATIENTS WITH CORONARY HEART DISEASE

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Биомедицина ва амалиёт журнали

Биомедицина ва амалиёт журнали

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One of the most important tasks of biological psychosomatics in the coming years is the search for biomarkers of anxiety depressive disorders (АDD) in patients with coronary heart disease (CHD). To assess the predictive value of the metabolites kynurenine pathway of tryptophan metabolism in the early diagnosis of TDS was examined 112 persons, of whom 84 patients with CHD and 28 healthy people. The study used psychometric, mass spectrometry and statistical methods. Depending on the presence of ADD in patients, revealed differences in the average concentration of KYN in the blood, the range of values obtained: from 1.76 μmol/l to 3.78 μmol/l KYN in patients with ADD and from 1.48 μmol/l to 2.98 μmol/l KYN of persons without affective disorders. Also, a positively high degree of correlation between the concentration of KYN in the blood and the severity of anxiety for HAS scale (r = 0.54; p = 0.05) and especially with the level of depression for HDS scale (r = 0.57; p = 0.01). The results indicate a susceptibility of CHD patients to severe ADD with increased production of the neurotoxic metabolite KYN.

AUTHORS

F.Abdumalikova

Тошкент тиббиёт академияси

Tags

# юрак ишемик касаллиги# ишемическая болезнь сердца# Coronary heart disease# тревожно-депрессивные состояния# нейротоксические метаболиты# anxiety-depressive disorders# neurotoxic metabolites# KYN# хавотир-депрессив ҳолатлар# нейротоксик биомаркерлар# кинуренин.

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Article Identifiers

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https://eroi.uz/11.0037/A0120-0009

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References

1. Shilov Yu.ye., Baymeeva N.V. i dr. (2014). Razrabotka novih metodov opredeleniya metabolitov triptofana dlya klinicheskoy praktiki [Development of new methods for determination of tryptophan metabolites for clinical practice]. Psixiatriya, 3, 56-62.

2. Abdulla A-B Badawy. (2017). Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects. Int J Tryptophan Res., 18, 10-18.

3. Åkesson K, Pettersson S. et al. (2018). Kynurenine pathway is altered in patients with SLE. Lupus Science & Medicine, 4, 50-57.

4. Kamiyu O. et al. (2018). Kynurenine pathway in depression: A systematic review and metaanalysis. Neuroscience and Bio. Reviews,90, 16–25.

5. Mangge H., I. Stelzer, et al. (2014). Disturbed tryptophan metabolism in cardiovascular disease. Curr. Med. Chem., 21, 1931–1937.

6. Plangar I., Vecsei L. (2012). Kynurenines in cognitive functions: their possible role in depression. Neuropsychopharmacol Hung., 14(4), 239-244.

7. Sulo G. et al. (2013). Neopterin and kynurenine–tryptophan ratio as predictors of coronary events in older adults. Int. J.Cardiol., 168, 1435–1440.

8. Xicong Liu. (2016). Imbalanced kynurenine pathway in schizophrenia and depression: immunological and genetic aspects. Acta Neuropsychiatrica, 13, 1-5.

9. Cipriani A., Zhou X. et al. (2016). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet, 388, 881-90.

10. Gan Y, Gong Y, Tong X, et al. (2014). Depression and the risk of coronary heart disease: a meta-analysis of prospective cohort studies. BMC Psychiatry,24 (14), 371

11. Notara V, Panagiotakos DB, Kogias Y. et al. (2016). The Impact of Educational Status on 10- Year (2004-2014) Cardiovascular Disease Prognosis and All-cause Mortality Among Acute Coronary Syndrome Patients in the Greek Acute Coronary Syndrome (GREECS) Longitudinal Study. J Prev Med Public Health, 49 (4), 220-9.

12. Doyle F, Rohde D, Rutkowska A. et al. (2014) Systematic review and meta-analysis of the impact of depression on subsequent smoking cessation in patients with coronary heart disease: 1990– 2013. Psychosom Med., 76, 44-57.

13. Sa M., Ying L., Tang A.G., Xiao L.D. (2014). Simultaneous determination of tyrosine, tryptophan and 5-hydroxytryptamine in serum of MDD patients by high performance liquid chromatography with fluorescence detection. Clin. Chim. Acta., 11-12, 973-977.

14. Zagajewski J., Drozdowicz D., Brzozowska I. et al. (2012). Conversion L tryptophan to melatonin in the gastrointestinal tract: the new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV-VIS detection. J. Physiol. Pharmacol., 63 (6), 613-621.

15. Wang H., Walaszczyk E.J., Li K., Chung-Davidson Y.W., Li W. (2016). High-performance liquid chromatography with fluorescence detection and ultra-performance liquid chromatography with electrospray tandem mass spectrometry method for the determination of indoleamine neurotransmitters and their metabolites in sea lamprey plasma. Anal. Chim. Acta.,721, 147-153.