Каламушларда гипертиреоз ёки гипотиреозни келтириб чиқариш учун ҳар куни меъда ичак тракти орқали L-тироксин (200 мкг/сутка 1 кг тана вазнига) ёки мерказолил (10 мг/сутка 1 кг тана вазнига) 14 ва 21 кун давомида берилди. Ҳайвонларга L-тироксин юборгандан сўнг қон зардобида тироксин миқдори 83 ва 136% га ошди, тиреотропгармон (ТТГ) миқдори эса камайди (56 ва 76%). Мерказолил юборилган каламушлар қон зардобида эркин тироксин миқдори 38 ва 62 % га камайди ва ТТГ миқдори 59 ва 550% га ошди, бунда эркин трийодтиронин миқдори 66 ва 74% га камайди. Экспериментал гипотиреоз қонда цистеин миқдорининг ошиши билан кечди (14 кунда 24% га ва 21 кунда 39% га). Мерказолил қўллагандан сўнг гомоцистеин миқдори ошди (98 ва 160%) ва гидроген сульфид миқдори камайди (17 ва 24%). Шундай қилиб, олтингугурт сақловчи аминокислоталар алмашинувининг бузилиши гипотиреоз билан оғриган беморларда кардиоваскуляр асоратлар ривожланишида маълум патогенетик роль уйнаши мумкин.
For hyperthyroidism and hypothyroidism modeling L-thyroxin (200 g/day per 1 kg of body weight) or merkazolil (10 mg/day per 1 kg of body weight) were administered to rats intraperitoneally daily for 14 and 21 days. Administration of L-thyroxin resulted in the increase of serum free thyroxin concentration by 83 and 136%, at the same time the thyroid-stimulating hormone level was significantly decreased (by 56 and 76%). Merkazolil caused the decrease of serum free thyroxine level by 38 and 62% and increase of thyroidstimulating hormone by 59 and 550%, while the level of free triiodothyronine was decreased by 66 and 74%. Experimental hypothyroidism was accompanied with the increase of cysteine level in blood (by 24% on 14th day and 39% on 21-st day). Merkazolil resulted also in the increase of homocysteine concentration (by 98 and 160%) and decrease of hydrogen sulphide level (by 17 and 24%). It has been concluded that disorders of sulfur amino acids metabolism could play a pathogenic role in the development of cardiovascular complications in patients with hypothyroidism.
| № | Author name | position | Name of organisation |
|---|---|---|---|
| 1 | Nechiporuk V.M. | ||
| 2 | Korda M.M. |
| № | Name of reference |
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