408

  • Read count 408
  • Date of publication 10-06-2020
  • Main LanguageO'zbek
  • Pages23-29
Tags
English

This review summarizes the current evidence on the role of cytokines in the pathogenesis of ischemic myocardial damage. It described
the important role of inflammation in the development of coronary heart disease. The role of individual cytokines in the pathogenesis
of coronary artery disease and the most frequent forms of it - angina. It is shown that in patients with coronary heart disease progression
of the disease is due to an imbalance in cytokine system, elevated pro-inflammatory cytokines (TNF, IL-1β, IL-6). Anti-inflammatory
cytokines (IL-4, IL-10) inhibit the secretion of proinflammatory cytokines by limiting excessive intensity of the immune response.
Revealed increasing levels of TGF-β1 as a key cytokine that promotes the development of fibrosis in the wall of the heart and blood
vessels. The interrelation between improving markers of inflammation and the development of coronary heart disease, the predictive
value of these markers of inflammation in patients with stable coronary heart disease: angina of effort of different functional classes.

№ Author name position Name of organisation
1 Alyavi A.L. д.м.н АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
2 Tulyaganova D.K. старший научный сотрудник АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
3 Nuritdinova S.K. старший преподаватель АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
4 Khan .A. младший научный сотрудник АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
5 Nazarova .A. младший научный сотрудник АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
6 Saidov S.B. младший научный сотрудник АО « Республиканский специализированный научно-практический медицинский центр терапии и медицинской реабилитации»
№ Name of reference
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