96 та эркак каламушлар тартибсиз равишда икки гуруҳга бўлинди. Тадқиқотнинг барча курси давомида каламушлар стандарт равишда озиқлантирилди ва тош ҳосил бўлиш индуктори сифатида 0,75% этиленгликоль бўлган ичимлик суви берилди. Буйракларда СаОх депозитлари пайдо бўлгандан сўнг, биринчи гуруҳдаги каламушлар аралашма экстрактини қабул қилишди, иккинчи, яъни назорат гуруҳидаги каламушлар эса плацебо қабул қилишди. Аралашма экстракти кучли диуретик таъсирга (69,1%) эга эканлиги аниқланди. Уролитиаз ингибиторлари ва промоутерларида ўзгаришлар кузатилди: сийдик рН ва и цитрат экскрециясининг ошиши, кальциурия ва оксалуриянинг камайиши. Сийдик йўлларида литогенез фаоллигининг пасайишини бирламчи кўрсаткичдан 70,86%гача АР[CaOx] индиксининг пасайганлиги тасдиқлади. Биз томондан ишлаб чиқилган сийдик хайдовчи фито аралашма табиий воситаларнинг нафақат сийдик хайдовчи, балки сийдик йўлларида литогенез омилларига таъсирини кўрсатди. Юқори диуретик таъсири ҳамда уролитиаз промоутер ва ингибиторларининг балансини нормаллаштириш хусусиятига эга эканлиги ҳисобга олиб, ушбу аралашмани уролитиаз билан оғриган беморларда даволаш мақсадида қўллаш мумкин.
The 96 male rats were randomly divided into two groups. The standard nutrition and drinking water with 0.75% EG as an inducer of stone formation were free for all rats. The first group received an extract from DG; the second group (control) received a placebo. The strong diuretic effect of the extract was found - by 69.1%. A significant change in inhibitors and promoters of urolithiasis was observed: an increase in urine pH and citrate excretion, a decrease in calciuria and oxaluria. The decrease in the activity of lithogenesis was confirmed by a decrease in the AP [CaOx] index by 70.86% from the baseline. The results confirm that diuretic plant has demonstrated the ability of herbal preparations, in addition to the diuretic effect, to influence on factors of urinary lithogenesis. The high diuretic effect in combination with ability of DG to normalise the balance of promoters and inhibitors, allows us to offer it for the management of patients with urolithiasis
| № | Author name | position | Name of organisation |
|---|---|---|---|
| 1 | Kariyev S.S. | Ташкентский институт усовершенствования врачей |
| № | Name of reference |
|---|---|
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