259

  • Web Address
  • DOI
  • Date of creation in the UzSCI system 14-04-2020
  • Read count 240
  • Date of publication 24-05-2019
  • Main LanguageRus
  • Pages144-147
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Ўзбек

Эркакларда фертилликнинг ҳар хил бузилиши даражаси билан контрикал билан даволанишдан олдин ва кейин сперманинг потеолитик ҳамда антипротеолитик фаоллиги, интерлейкин, TGF-β ўрганилди. Тадқиқот натижаларидан қуйидаги хулосага келинди, контрикалнинг эркаклар спермасини иммун коррекция қилувчи сифатида қўлланиши унинг иммун тавсифини яхшилаш, шунингдек, сперманинг антипротеолитик фаоллигининг пасайиши ҳамда протеолитик фаоллигининг ошишига сабаб бўлади. Бундай ўзгаришлар сперманинг фертил хусусиятини яхшилайди

English

In men with varying degrees of impaired fertility, interleukins, TGF-β, poteolytic and antiproteolytic activity of sperm were investigated before and after contrical treatment. It was concluded that the use of the drug contrycal as an immunocorrective factor of male sperm contributes to the improvement of its immune characteristics, as well as a decrease in antiproteolytic and an increase in proteolytic activity of sperm. These changes improve the fertile properties of sperm

№ Author name position Name of organisation
1 Xojimatov G.M.
№ Name of reference
1 1. Desser L. et al. Oral therapy with proteolytic enzymes decreases excessive TGF-β levels in human blood //Cancer chemotherapy and pharmacology. – 2001. – Т. 47. – №. 1. – С. S10-S15. 2. Johansson M. et al. Semen activates the female immune response during early pregnancy in mice //Immunology. – 2004. – Т. 112. – №. 2. – С. 290-300. 3. Jones R. L. et al. TGF-β superfamily expression and actions in the endometrium and placenta //Reproduction. – 2006. – Т. 132. – №. 2. – С. 217-232. 4. Krol J., Kowalski R., Demska-Zakęś K., Hliwa P., Glogowski J. Proteolytic and anti-proteolytic activity in the seminal plasma of Eurasian perch (PercafluviatilisL.) during the spawning period. Czech J. Anim. Sci., 2011, vol. 56, no9, 390–397. 5. Kubiczkova L. et al. TGF-β–an excellent servant but a bad master //Journal of translational medicine. – 2012. – Т. 10. – №. 1. – С. 183. 6. Lauer D. et al. Modulation of growth factor binding properties of a2-macroglobulin by enzyme therapy //Cancer chemotherapy and pharmacology. – 2001. – Т. 47. – №. 1. – С. S4-S9. 7. McCaffrey T. A. et al. Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex //The Journal of Cell Biology. – 1989. – Т. 109. – №. 1. – С. 441-448. 8. Nelson S. M., Greer I. A. The potential role of heparin in assisted conception //Human Reproduction Update. – 2008. – Т. 14. – №. 6. – С. 623-645. 9. Robertson S. A. Seminal plasma and male factor signalling in the female reproductive tract //Cell and tissue research. – 2005. – Т. 322. – №. 1. – С. 43-52. 10. Sadat Z., Kalahroudi M. A., Saberi F. The effect of short duration sperm exposure on development of preeclampsia in primigravid women //Iranian Red Crescent Medical Journal. – 2012. – Т. 14. – №. 1. – С. 20. 11. Shadmanov A., Aleynik V., Babich S. at all. Therapeutic effects on performance wobenzymproteolytic and antiproteolitic activity in men with sperm impaired fertility. European applied sciences, Stuttgart, Germany, 2014, no 3, 47-48. 12. Yang L., Pang Y., Moses H. L. TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression //Trends in immunology. – 2010. – Т. 31. – №. 6. – С. 220-227.
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