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The article presents information about amygdalin and its chemical properties, which belongs to the class of natural cyanoglycosides.The article also mentions the importance of amygdalin in the treatment of various diseases, such as asthma, bronchitis, emphysema of the lungs, pulmonary fibrosis, diseases of the gastrointestinal tract, oncological diseases, kidney diseases.

  • Internet ҳавола
  • DOI
  • UzSCI тизимида яратилган сана 20-09-2022
  • Ўқишлар сони 0
  • Нашр санаси 20-10-2021
  • Мақола тилиIngliz
  • Саҳифалар сони42-48
Ўзбек

Мақолада табиий цианогликозидлар синфига кирувчи амигдалин ва унинг кимёвий хоссалари тўғрисида маълумотлар келтирилган. Мақолада амигдалиннинг астма, бронхит, эмфизема, ўпка фибрози, ошқозон-ичак касалликлари, саратон, буйрак касалликлари каби турли хил касалликларни даволашдаги аҳамияти ҳақида ҳам сўз юритилган.

Русский

В статье представлена информация об амигдалине и его химических свойствах, который относится к классу природных цианогликозидов. В статье также упоминается важность амигдалина в лечении различных заболеваний, таких как астма, бронхит,  эмфизема легких, фиброз легких, заболевания желудочно-кишечного тракта, онкологические заболевания, заболевания почек и других.

English

The article presents information about amygdalin and its chemical properties, which belongs to the class of natural cyanoglycosides.The article also mentions the importance of amygdalin in the treatment of various diseases, such as asthma, bronchitis, emphysema of the lungs, pulmonary fibrosis, diseases of the gastrointestinal tract, oncological diseases, kidney diseases.

№ Муаллифнинг исми Лавозими Ташкилот номи
1 Abdugapparov F.S. 2 Andijan State University
2 Xojimatov M.M. 3 Andijan State University
3 Asqarov I.R. 1 Andijan State University
№ Ҳавола номи
1 1. Araya E, Rodriguez A, Rubio J et al. Synthesisand evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T. Bioorg. Med. Chem. Lett. 15,1493–1496 (2005).
2 2. ChristopheBliard∗GeorgesMassiotSergeNazabadioko Amygdalin as building block in oligosaccharide synthesis Tetrahedron Letters Volume 34, Issue 32, 6 August 1993, Pages 5083-5084 https://doi.org/10.1016/S0040-4039(00)60681-0
3 3. Amit Lather, Sunil Sharma , Anurag Khatkar. Amygdalin based G-6-P synthase inhibitors as novel preservatives for food and harmaceutical products. Scientific RepoRtS | (2020) 10:1390-1393. https://doi.org/10.1038/s41598-020-70895- 1
4 4. Islamiyat Folashade Bolarinwa. Synthesis and Characterization of Hapten-Protein Conjugates for Antibody Production against Cyanogenic Glycosides. Journal of Food Protection, Vol. 78, No. 7, 2015, Pages 1408–1413. doi:10.4315/0362-028X.JFP-15-033
5 5. Rabia Sohail, Shah Rukh Abbas. Evaluation of amygdalin-loaded alginate-chitosan nanoparticles as biocompatible drug delivery carriers for anticancerous efficacy. International Journal of Biological Macromolecules 153 (2020) 36–45.
6 6. Chan TY. A probable case of amygdalin-induced peripheral neuropathy in a vegetarian with vitamin B12 deficiency. Ther Drug Monit 2006;28:140.
7 7. Chang HK, Yang HY, Lee TH, Shin MC, Lee MH, Shin MS, et al.Armeniacae semen extract suppresses lipopolysaccharide-induced expressions of cyclooxygenase [correction of cycloosygenase]-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. Biol Pharm Bull 2005;28:449-454.
8 8. Chang HK, Shin MS, Yang HY, Lee JW, Kim YS, Lee MH, et al. Amygdalin induces apoptosis through regulation of Bax and Bcl-2 expressions in human DU145 and LNCaP prostate cancer cells. Biol Pharm Bull 2006;29:1597-602.
9 9. Park HJ, Yoon SH, Han LS, Zheng LT, Jung KH, Uhm YK, et al. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol 2005;11:5156-5161.
10 10. Guo J, Wu W, Sheng M, Yang S, Tan J. Amygdalin inhibits renal fibrosis in chronic kidney disease. Mol Med Rep 2013;7:1453-1457.
11 11. Baroni A, Paoletti I, Greco R, Satriano RA, Ruocco E, Tufano MA, et al. Immunomodulatory effects of a set of amygdalin analogues on human keratinocyte cells. Exp Dermatol 2005;14:854-859.
12 12. Mirmiranpour H, Khaghani S, Zandieh A, Khalilzadeh OO,Gerayesh-Nejad S, Morteza A, et al. Amygdalin inhibits angiogenesisin the cultured endothelial cells of diabetic rats. Indian J PatholMicrobiol 2012;55:211-214.
13 13. Liu C, Li X, Yang H, Mao X, Wang J, Gao W. Effect of Natural beta-Glucosidase Inhibitors in Reducing Toxicity of Amygdalin in Persicae Semen. Phytother Res. 2017; 31(5): 771–777. doi: 10.1002/ptr.5798.
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