Ҳаммаси бўлиб, 12 нафар аёллар вақтидан олдин туққан, бу эса 14,12% ни ташкил этди. Улардан 8 нафарида цервикал канал секрециясида плацентар α1-микроглобулин миқдори аниқланди, айни пайтда фақат 5 нафар аёлларда УТТ цервикометрия натижасига кўра ≤20 мм ни ташкил этди. Вақтидан олдин туққан 4 нафар аёлларда (48 соатдан 7 сутка давомида) нотўғри салбий натижани кўрсатди. 7 (8,2%) нафар аёлда плацентар α1-микроглобулин тест синамаси мусбат бўлди ва бу беморларда кескин туғруқ бошланди. Плацентар α1-микроглобулинни вақтидан олдин туғруқнинг сезгирлик синамаси 66,67% ни, спецификлик - 95,9%, УТТ цервикометрия спецификлиги - 47,9%, сезгирлик - 41,7% ни ташкил этди. Иккала усулни тандемда ишлатиш вақтидан олдин туғиш хавфини кескин тушириши мумкин. Цервикометрия натижасига кўра, бачадон буйни қисқа бўлган аёлларга цервикал каналда α1-микроглобулин миқдорини тест-синамасини ўтказиш тавсия этилади
Total of 12 patients had premature labour accounting for 14.12%. In 8 of them placental α1-microglobulin incervical secretion was positive and only in 5 patients cervical length was ≤20 mm according to ultrasound cervicometry.4 patients with premature birth (ranging from 48 hours to 7 days) had false-negative test results. 7 (8.2%) patients hada false-positive result of placental α1-microglobulin test, and these patients subsequently had term birth. The sensitivity of the test for placental α1-microglobulin as a marker of premature birth was 66.67%, specificity 95.9%, specificity ofultrasound cervicometry - 47.9%, and sensitivity - 41.7%. Use of the combination of both tests can significantlyreduce hyperdiagnosis of threatened preterm labour. Females with short cervix according to ultrasound cervicometry should reasonably be tested forplacental α1-microglobulin in cervical discharge; positive result of this test will be found in those whose probability togive preterm labour during the next 14 days reaches 72.72%, and high prognostic value of a negative test result allowsobserving the patients in outpatient setting
| № | Муаллифнинг исми | Лавозими | Ташкилот номи |
|---|---|---|---|
| 1 | Shavazi N.N. |
| № | Ҳавола номи |
|---|---|
| 1 | 1. Савельева Г.М., Шалина Р.И., Плеханова Е.Р. и др. Современные проблемы преждевременных родов. Рос.вестн. акушера-гинеколога. 2010; (3): 52–59. 2010; (3): 52–59. 2. Ходжаева З.С., Сидельникова В.М. Эффективность применения новых диагностических тестовдля определения начала родовой деятельности и не-своевременного излития околоплодных вод. Вопр.гинекол., акушерстваиперинатол. 2007; 6 (1): 47–51. 2007; 6 (1): 47–51. 3. Alfirevic Z., Allen Coward F., Molina F. et al. Targeted therapy for threatened preterm labor based on sonographic measurement of the cervical length: a randomized controlled trial. Ultrasound Obstet. Gynecol. 2007; (29): 47–50. 4. Gomez R., Romero R., Medina L. e t a l. Cervicovaginalfibronectin improves the prediction of preterm delivery based on sonographic cervical length in patients with preterm uterine contractions and intact membranes. Am. J. Obstetr. Gynecol. 2005; (192): 350–359. 5. Petrunin D. Immunochemical identification of organ specific human placental alpha-globulin and its concentration in amniotic fluid. Akush.Ginekol. 1977; (1): 64–65. 6. Romero R., Nicolaides K., Conde-Agudelo A. et al. Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreasespreterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am. J.Obstet. Gynecol. 2012; 206 (2): 124. 7. World Health Organization. WHO: recommended definitions, terminology and format for statistical tablesrelated to the perinatal period and use of a new certificate for cause of perinatal deaths. Modifications recommended by FIGO as amended October 14, 1976. Acta Obstet.Gynecol. Scand. - 1977; 59. 247–253. 8. Lee S.M., Romero R., Park J.W. et al. The clinicalsignificance of a positive Amnisure test (™) in women with preterm labor and intact membranes.J. Matern. Fetal Neonatal Med. 2012; 25 (9): 1690–1698. |