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The introductory part of this article provides literature data on the chemical composition of licorice, which is a medicinal plant, on drugs obtained from it, as well as on a number of glycyrrhizic acid derivatives obtained by Russian scientists and authors, on the biological properties of the compounds obtained. The main part of the article discusses the results of studying the structure and biological activity of supramolecular complexes of monoammonium salt of glycyrrhizic acid with urea using UV-IR spectra, the image of the spectrum, and the probable chemical formula of the structure of the complex are presented. Based on spectral data, it was concluded that amino and hydroxyl groups of the components are involved in complexation. A classification of the resulting complex compound according to the Commodity Nomenclature of Foreign Economic Activity (CN FEA) and the corresponding product code for it are proposed.
 

  • Ссылка в интернете
  • DOI
  • Дата создание в систему UzSCI 21-10-2020
  • Количество прочтений 184
  • Дата публикации 20-06-2020
  • Язык статьиIngliz
  • Страницы171-175
English 

The introductory part of this article provides literature data on the chemical composition of licorice, which is a medicinal plant, on drugs obtained from it, as well as on a number of glycyrrhizic acid derivatives obtained by Russian scientists and authors, on the biological properties of the compounds obtained. The main part of the article discusses the results of studying the structure and biological activity of supramolecular complexes of monoammonium salt of glycyrrhizic acid with urea using UV-IR spectra, the image of the spectrum, and the probable chemical formula of the structure of the complex are presented. Based on spectral data, it was concluded that amino and hydroxyl groups of the components are involved in complexation. A classification of the resulting complex compound according to the Commodity Nomenclature of Foreign Economic Activity (CN FEA) and the corresponding product code for it are proposed.
 

№ Имя автора Должность Наименование организации
1 Isaev S.A. o'qituvchio 1Andijan State University
2 Isaev Y.T. o'qituvchi 1Andijan State University
3 Rustamov S.A. o'qituvchi 1Andijan State University
4 Khozhimatov M.M. o'qituvchi 1Andijan State University
5 Askarov I.R. o'qituvchi 2Federal State Budget Scientific Institution Federal Scientific
№ Название ссылки
1 1. G.A. Tolstikov, A.A. Baltina, V.P. Grankina, R. M. Kodratenkova. LIQUORINE Biodiversity, chemistry, medical applications. Novosibirsk Academic Publishing House “GEO”. 2007. P. 260-272.
2 2. Tolstikov G.A., Baltina L.A., Schulz E.E., Pokrovsky A.G. Glycyrrhizic acid (review). // Bioorganic chemistry, 1997. V. 23, No. 9. P.–691–709.
3 3. Isaev Yu.T. Derivatives of glycyrrhizic acid and their biological activity. Abstract. diss. Cand. Chem. sciences. Tashkent. 2001. 25 P.
4 4. Isaev Yu.T., Rustamov S.A., Askarov I.R. Synthesis of urea and thiourea containing derivatives of glycyrrhizic acid and their biological activity. Scientific Bulletin of AndSU. 2018. - No. 4. P. - 26-29.
5 5. Astafyeva OV Uses of Glycyrrhiza glabra, Achilleamicrantha willd. and Helichrysum arenarium L. for the development of biological products with antibacterial properties. Abstract. diss. Cand. sciences. Stavropol. 2013. P -13-14.
6 6. Kondratenko R.M. Glycyrrhizic acid and related licorice triterpenoids in the synthesis of promising biologically active compounds. Abstract. diss. Cand. sciences. Ufa 2006. P. 4.
7 7. 7. Isaev Yu.T., Rustamov S.A., Askarov I.R. Synthesis of thymourea-containing derivatives of glycyrrhizic acid. “Bulletin of the Perm State Pharmaceutical Academy.” Scientific and practical journal. -2018, No. 22. P. 34-35.
8 8. 8. Dalimov D.N., Isaev Yu.T., Sayitkulov A.M. Molecular complexes of the monoammonium salt of glycyrrhizic acid with certain drugs and their interferon-inducing activity // Chemistry nat.conn. -2001, No. 2. P. 132-134.
9 9. Isaev Yu.T., Rustamov S.A., Askarov I.R. Studying of bioactivity of glycyrrhizic acid and biuret complexes. Scientific Bulletin of AndSU. 2019. - No. 3. P. - 92-97.
10 10. I.R.Askarov, Yu.T.Isaev, S.A. Rustamov, U.M.Yakubov. Prospects for the use of glycyrrhizic acidde rivatives. //XIII International Symposium on the Chemistry of Natural Compounds. October 16-19. 2019. P. 62. Shanghai. China.
11 11. Yu.T.Isaev, D.N.Dalimov, N.N.Tukhtabaeva. Influence of metal ion-containing compounds on glycyrrhizic acid in the yield of seeds / Scientific Bulletin of AndSU. 2015. No. 1. P. 21-24.
12 12. Khodzhimatov M.M. Autoref. PhD (2018). Synthesis and classification of Ferrottsen and Methylolmochevina derivatives. Andijan. 25 P.
13 13. Kushiev H. Autooreph. DSc (2010). Management of the effects of biotic and abiotic factors on the growth and development of wheat using physiologically active substances. Tashkent. B. 20-22.
14 14. Tulakov N.Q. Autooreph. PhD (2018). Synthesis and classification of some derivatives of ferrocenocarbonic acid. Andijan. 28 P.
15 15. Hodzhimatov M.M. Classification of ferrocene and urea derivatives. Scientific Notification. Andijan. 2019-No.3. –P. 67-76.
16 16. Commodity nomenclature of foreign economic activity of the Republic of Uzbekistan. Tashkent. 2017.
17 17. Askarov I.R. «Chemistry of goods» is a new science in the system of chemical sciences. Materials of the 5th Republican scientific-practical conference on the problems and perspectives of commodity chemistry (with participation of international scientists). Andijan, September 4-5, 2018 –P. 21-23.
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