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Ўткир респиратор синдромли коронавирус Corona Virus Disease 2019 пандемияси глобал соғлиқни сақлаш тизимига жиддий хавф туғдирмоқда. Ҳозирда биз бутун дунё бўйлаб клиник тадқиқотлар сонининг ортиб бораётганига гувоҳ бўлмоқдамиз. Клиник тадқиқотларда дорилар, шу жумладан, замонавий ва олдинги замон дори воситаларининг потенциал даволаш усуллари сифатида ёки уларнинг вирусга қарши фаоллиги ҳамда Corona Virus Disease 2019 инфекциясига хос бўлган нафас ва юрак-қон томир белгилари ва асоратларига таъсир қилиш қобилияти клиник тадқиқот синовларидан ўтмоқда. Corona Virus Disease 2019 инфекциясининг ёмон тенденциясига қарамай, кенг кўламли тадқиқотларда бирон-бир дори воситасининг Corona Virus Disease 2019 билан оғриган беморларни клиник даволашда сезиларли даражада самарадор эканлиги исботланмаган. Бундай стратегия терапияни персонификация қилиш учун хавф гуруҳларини аниқлашда дастлабки фармакогенетик тадқиқотлар ёрдамида ечилиши мумкин бўлган хавфсизлик ва самарадорлик борасида бир қатор муаммоларга олиб келиши мумкин. Corona Virus Disease 2019 инфекцияси тиббий даволашнинг персонификация масаласини ҳал қилиш клиник тадқиқотларнинг қарама-қарши натижаларини талқин қилиш ва маълум бир дори воситасининг аниқ самарадорлигини аниқлаш учун зарурий эҳтиёжга айланади

  • Ссылка в интернете
  • DOIhttps://dx.doi.org/10.36522/2181-9637-2020-4-12
  • Дата создание в систему UzSCI 07-04-2022
  • Количество прочтений 236
  • Дата публикации 10-09-2020
  • Язык статьиO'zbek
  • Страницы123-133
Ўзбек

Ўткир респиратор синдромли коронавирус Corona Virus Disease 2019 пандемияси глобал соғлиқни сақлаш тизимига жиддий хавф туғдирмоқда. Ҳозирда биз бутун дунё бўйлаб клиник тадқиқотлар сонининг ортиб бораётганига гувоҳ бўлмоқдамиз. Клиник тадқиқотларда дорилар, шу жумладан, замонавий ва олдинги замон дори воситаларининг потенциал даволаш усуллари сифатида ёки уларнинг вирусга қарши фаоллиги ҳамда Corona Virus Disease 2019 инфекциясига хос бўлган нафас ва юрак-қон томир белгилари ва асоратларига таъсир қилиш қобилияти клиник тадқиқот синовларидан ўтмоқда. Corona Virus Disease 2019 инфекциясининг ёмон тенденциясига қарамай, кенг кўламли тадқиқотларда бирон-бир дори воситасининг Corona Virus Disease 2019 билан оғриган беморларни клиник даволашда сезиларли даражада самарадор эканлиги исботланмаган. Бундай стратегия терапияни персонификация қилиш учун хавф гуруҳларини аниқлашда дастлабки фармакогенетик тадқиқотлар ёрдамида ечилиши мумкин бўлган хавфсизлик ва самарадорлик борасида бир қатор муаммоларга олиб келиши мумкин. Corona Virus Disease 2019 инфекцияси тиббий даволашнинг персонификация масаласини ҳал қилиш клиник тадқиқотларнинг қарама-қарши натижаларини талқин қилиш ва маълум бир дори воситасининг аниқ самарадорлигини аниқлаш учун зарурий эҳтиёжга айланади

Русский

Пандемия Corona Virus Disease 2019, вызванная SARS-CoV-2 – коронавирусом тяжелого острого респираторного синдрома, представляет собой серьезную глобальную угрозу для мирового здравоохранения. Во всем мире проводятся клинические исследования старых и новых препаратов в качестве потенциальных методов лечения по их прямой антивирусной активности или способности обеспечить воздействие на респираторные, сердечно-сосудистые симптомы и другие осложнения, характерные для коронавирусной инфекции. Проведенными исследованиями до сих пор не доказана значительная эффективность ни одного лекарственного препарата при клиническом лечении больных Corona Virus Disease 2019. Такая стратегия может привести к ряду проблем безопасности и эффективности, которые могут быть решены с помощью подхода предварительного проведения фармакогенетических исследований по выделению групп риска для персонификации терапии. Решение задачи персонификации медикаментозного лечения Corona Virus Disease 2019 становится настоятельной необходимостью в интерпретации полученных противоречивых результатов клинических испытаний и установления явной эффективности какого-либо конкретного препарата

English

The pandemic of Corona Virus Disease 2019 infection, caused by severe acute respiratory syndrome coronavirus, has posed a significant threat to global health. We are now witnessing an unsurpassed increase in the number of clinical trials worldwide. Old and new drugs are tested in clinical trials as potential treatments either for their direct anti-viral activity or for their ability to induce effects on respiratory and cardiovascular symptoms and complications specific to Corona Virus. Despite the law trends of Corona Virus, large-scale studies have not proven significant effectiveness in the clinical treatment of patients with coronavirus 2019. Such a strategy is likely to give rise to a range of safety and efficacy challenges that could be addressed through preliminary pharmaco-genetic studies to identify the risk groups for personification of therapy approach. Addressing the personification of drug treatment Corona Virus Disease 2019 becomes an urgent need to interpret the conflicting results of clinical trials and establish the apparent efficacy of any particular drug.

№ Имя автора Должность Наименование организации
1 Mavlyanov I.R. tibbiyot fanlari doktori, professor, “Klinik farmakologiya” kafedrasi mudiri Toshkent vrachlar malakasini oshirish instituti
2 Mavlyanov Z.I. tibbiyot fanlari doktori, “Klinik farmakologiya” kafedrasi dotsenti Toshkent vrachlar malakasini oshirish instituti
3 Ashirmetov A.X. tibbiyot fanlari doktori, katta ilmiy xodim, yetakchi mutaxassis O'zbekiston Respublikasi Sog'liqni saqlash vazirligi
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