306

Тадқиқот мақсади ярали колит билан касалланган беморлар ҳужайравий 
ва гуморал иммун холатига гельминтлар ва содда жонворланинг таъсирини аниқлаш. Ярали колит билан касалланган беморларда бластоцистоз умумий 
носпецифик  IgE  ва  яллиғланиш  олди  ФНО-αва  ИФН-γ  цитокинларининг 
ишончли  кўтарилишига  олиб  келди.  Ярали  колит  билан  касалланган 
беморларда  бошқа  ичак  паразитозлари  иммунологик  кўрсаткичларда 
ишончли  даражада  ўзгаришларга  олиб  келмади.  Бу  эса  Ўзбекистон  учун 
эндемик  бўлган  ичак  паразитозларининг  (аскаридоз,  энтеробиоз, 
гименолепидоз  и  лямблиоз)  ярали  колит  этиопатогенезида  роли  мавжуд 
эмаслигини тасдиқлайди. 

  • Ссылка в интернете
  • DOI
  • Дата создание в систему UzSCI 30-04-2020
  • Количество прочтений 276
  • Дата публикации 07-10-2019
  • Язык статьиO'zbek
  • Страницы238-254
Ўзбек

Тадқиқот мақсади ярали колит билан касалланган беморлар ҳужайравий 
ва гуморал иммун холатига гельминтлар ва содда жонворланинг таъсирини аниқлаш. Ярали колит билан касалланган беморларда бластоцистоз умумий 
носпецифик  IgE  ва  яллиғланиш  олди  ФНО-αва  ИФН-γ  цитокинларининг 
ишончли  кўтарилишига  олиб  келди.  Ярали  колит  билан  касалланган 
беморларда  бошқа  ичак  паразитозлари  иммунологик  кўрсаткичларда 
ишончли  даражада  ўзгаришларга  олиб  келмади.  Бу  эса  Ўзбекистон  учун 
эндемик  бўлган  ичак  паразитозларининг  (аскаридоз,  энтеробиоз, 
гименолепидоз  и  лямблиоз)  ярали  колит  этиопатогенезида  роли  мавжуд 
эмаслигини тасдиқлайди. 

English

The  aim  of  the  study  is  to  determine  the  influence  of  helminths  and 
pathogenic  protozoa  on  the  status  of  cellular  and  humoral  immunity  in  UC 
patients.  In  patients  with  UC,  blastocystosis  significantly  increased  the  level  of 
total  serum  non-specific  IgE  and  pro-inflammatory  cytokines  TNF-α  and  IFN-γ. 
Changes  in  immunological  parameters  with  other  concomitant  intestinal 
parasitoses in UC patients were absent or slightly expressed, which  indicates the 
absence  of  the  role  of  intestinal  parasitoses  endemic  to  Uzbekistan  (ascariasis, 
enterobiosis, hymenolepidosis and giardiasis) in the etiology and pathogenesis of 
UC. 

№ Название ссылки
1 1. Осипова С.О. Иммунологические аспекты взаимоотношений ―хозяин-паразит‖ при лямблиозе. Автореф. ..дис. докт. мед. наук. М., 1987. – 38 с. 2. ТутинаO.A. Клинико-иммунологическая характеристика и коррекция терапии хронических воспалительных заболеваний кишечника у детей. Автореф. дис. …канд. мед.наук. 2010. M., 25 с. 3. Макарова И.А., Астафьев Б.А. Клинико-иммунологическая характеристика гименолепидоза . Мед. паразитол. (Москва). 1992. №3. – С.40-42 4. Залялиева М.В., Прохорова Р.С. Способ определения субпопуляций лимфоцитов. // Расмийахборот. – 2001. – N4. – C.12–14. 5. Ajami, A.,Rafiei A. Cytokine production in Нymenolepis nana infection. Iran J. Immunol. 2007. Dex. 4(4):L 236-40. (2007) 6. Babaei Z.,Malihi N. , Zia-Ali, N. IrajSharifi, Mohammad A. Mohammadi,Martin F. KagnoffM.F.,LarsEckmann, Steven M. Singer, and ShahramSolaymani-Mohammadi. S. Adaptive immune response in symptomatic and asymptomatic enteric protozoal infection: evidence for a determining role of parasite genetic heterogeneity in host immunity to human giardiasis.Microbes Infect. 2016 Nov; 18(11): 687–695. 7. Buendía E.,Zakzuk J., Mercado L.,Alvarez A., Caraballo L. The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity. World Allergy Organ J. 2015; 8(1): 8. 8. Buzza MS, Johnson TA, Conway GD, Martin EW, Mukhopadhyay S, Shea- Donohue T, Antalis TM. Inflammatory cytokines down-regulate the barrier- protective prostasin-matriptase proteolytic cascade early in experimental colitis.J Biol Chem. 2017 Jun 30;292(26):10801-10812. 9. Cao W, Vrees MD, Potenti FM, Harnett KM, Fiocchi C, Pricolo VE. Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. Journal of Pharmacology and Experimental Therapeutics. 2004;311(1):60–70. 10. Chandramathi S, Suresh K, Sivanandam S 1 , Kuppusamy UR. Stress exacerbates infectivity and pathogenicity of Blastocystis hominis: in vitro and in vivo evidences. PLoS One. 2014 May 2;9(5):e94567. 11. D'Haens G, Sandborn WJ, Feagan BG, Geboes K, Hanauer SB, Irvine EJ, Lémann M, Marteau P, Rutgeerts P, Schölmerich J, Sutherland LR. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis.Gastroenterology. 2007Feb;132(2):763-86. 12. Gabrie JA, Rueda MM, Rodríguez CA, Canales M, Sanchez AL Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths. J Parasitol Res. 2016;2016:1769585. 13. Hanevik,K. Kristoffersen E. K. ,Sørnes S. , Mørch K., 2 Næss H., Rivenes, A.C. 6 Jørn E Bødtker, J.E. 7 Hausken T., Langeland N. Immunophenotyping in post- giardiasis functional gastrointestinal disease and chronic fatigue syndrome. BMC Infect Dis. 2012; 12: 258. 14. Halliez M. C.M., Buretv A. G. Extra-intestinal and long term consequences of Giardia duodenalis infections. World J Gastroenterol. 2013 Dec 21; 19(47): 8974–8985. 15. Hoving J. C., Kirstein F., Nieuwenhuizen N. E., Fick L. C., Hobeika E., Reth M., et al. . (2012). B cells that produce immunoglobulin E mediate colitis in BALB/c mice. Gastroenterology. 2012. 142, 96–108 16. Hoving J.C. Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis.Front Cell Infect Microbiol. 2018; 8: 395. 17. Iguchi A, Yoshikawa H, Yamada M, Kimata I, Arizono N. Expression of interferon gamma and proinflammatory cytokines in the cecal mucosa of rats experimentally infected with Blastocystissp. strain RN94-9. Parasitol Res. 2009 Jul;105(1):135-40 18. Jagger AL, Evans HG, Walter GJ, et al. FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25− responder T cells, but not CD4+CD25+ regulatory T cells. J Autoimmun. 2012;38:29–38 19. Kapczuk P.,Kosik-Bogacka D.,Łanocha-Arendarczyk N. et al., Izabela Gutowska, PatrycjaKupnicka, DariuszChlubek and Irena Baranowska-Bosiacka1, Selected Molecular Mechanisms Involved in the Parasite–Host System Hymenolepisdiminuta–RattusnorvegicusInt J Mol Sci. 2018 Aug; 19(8): 2435. 20. Keselman A., Li E. Maloney J., Singer S.M. The Microbiota Contributes to CD8 + T Cell Activation and Nutrient Malabsorption following Intestinal Infection with Giardia duodenalis. Infect Immun. 2016 Oct; 84(10): 2853–2860. 21. Kotlyar D.S., Shum M., Hsieh J.,Blonski W and Greenwald D.A. Non- pulmonary allergic diseases and inflammatory bowel disease: A qualitative review. World J Gastroenterol. 2014 Aug 28; 20(32): 11023–11032. 22. Korolkova O.Y., Myers J.N.,… and M’Koma. Characterization of serum cytokine profile in predominantly colonic inflammatory bowel disease to delineate ulcerative and Crohn’s colitides . Clin. Med. Insights Gastroenterol. 2015;8: 29- 44 23. Kumarasamy V, Kuppusamy UR, Jayalakshmi P, Samudi C, Ragavan ND, Kumar S Exacerbation of colon carcinogenesis by Blastocystis sp. PLoS One. 2017 Aug 31;12(8):e0183097. 24. Lawrance IC. Early investigational TNF receptor antagonists for the treatment of ulcerative colitis. Expert OpinInvestig Drugs. 2015 Jun;24(6):761-8 25. Lee R.W., Creed T.J., Schwitz I.P., Newcomb L.B., et al. CD4+CD25+ T cells in inflammatory diseases refractory to treatment with glucocorticoids. J. Immunol. 2007. Dec; 179(11):7941-8. 26. Mancini G., Carbonara A., Heremans J. Immunochemical quantitation of antigen by single radial immunodiffusion. // Immunochemistry. – 1965 – № 2. – Р. 235-248. 27. Műzes G.,Molnár B., Tulassay Z., Sipos F. Changes of the cytokine profile in inflammatory bowel diseases. World J Gastroenterol. 2012 Nov 7; 18(41): 5848–5861. 28. Mittal RD, Bid HK, Ghoshal UC. IL-1 receptor antagonist (IL-1Ra) gene polymorphism in patients with inflammatory bowel disease in India. Scandinavian Journal of Gastroenterology. 2005;40(7):827–831. 29. Naglaa M Shalaby and Nehad M Shalaby Effect of Ascaris lumbricoides infection on T helper cell type 2 in rural Egyptian children.TherClin Risk Manag. 2016; 12: 379–385. 30. Neil GA, Summers RW, Cheyne BA, Carpenter C, Huang WL, Waldschmidt TJ. Analysis of T-lymphocyte subpopulations in inflammatory bowel diseases by three-color flow cytometry.Dig Dis Sci. 1994 Sep;39(9):1900-8. 31. Neubauer K., Wozniak-Stolarska B., Krzystek-Korpacka M. Peripheral lymphocytes of patients with iunflammatory bowel diseases have altered concentrations of key apoptosis players: preliminary results. Biomed. Res.Int. 2018; 2018:4961753.Published online 2018 Nov 1. 32. Patsantara GG, Piperaki ET, Tzoumaka-Bakoula C, Kanariou MG Immune responses in children infected with the pinworm Enterobius vermicularis in central Greece. J Helminthol. 2016 May;90(3):337-41. 33. Ping Wu, YonggaoGuo, FangyuanJia, and Xiuli Wang The Effects of Armillarisin A on Serum IL-1β and IL-4 and in Treating Ulcerative Colitis.CellBiochemBiophys. 2015; 72(1): 103–106. 34. RaweeratSitcharungsi, ChukiatSirivichayakul Allergic diseases and helminth infections.Pathog Glob Health. 2013 Apr; 107(3): 110–115. 35. Rodríguez-PerálvarezML, García-SánchezV, Villar-PastorCM, GonzálezR, Iglesias-FloresE, MuntaneJ, Gómez-CamachoF. Role of serum cytokine profile in ulcerative colitis assessment. Inflamm Bowel Dis.2012 Oct;18(10):1864-71. 36. Sato S., Chiva T., Nakamura S., Matsumoto J. Changes in cytokine profile may predict therapeutic efficacy of infliximab in patients with ulcerative colitis. J. Gastroenterol. Hepatol. 2015 Oct30(10):1467-72. 37. Serradell M.C., Gargantini P.R.,Saura A. ,a,bSergio R. Oms,aLucía L. Rupil,a,bLucianaBerod,cSparwasser T, Luján H.D.. Cytokines, Antibodies, and Histopathological Profiles during Giardia Infection and Variant-Specific Surface Protein-Based Vaccination Infect Immun. 2018 Jun; 86(6): e00773-17. 38. Silverberg MS, Satsangi J, Ahmad T, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.Can J Gastroenterol. 2005 Sep;19 Suppl A:5A-36A. 39. Song L, Zhou R, Huang S, Zhou F, Xu S, Wang W, Yi F, Wang X, Xia B High intestinal and systemic levels of interleukin-23/T-helper 17 pathway in Chinese patients with inflammatory bowel disease.MediatorsInflamm. 2013;2013:425915. 40. Steel A.W., Mela C.M., Lindsay J.O., Gazzard B.G., Goodier M.R. increased proportion of CD16+ NK cells in the colonic lamina propria of inflammatory bowel disease patients, but not after azathioprine treatments. Aliment. PharmacolTher. 2011. Jan. 33 (1):115-26. 41. Strober W., Fuss U. Proinflammatory cytokines in the pathogenesis of inflsammstory bowel diseasaes. Gastroenterology. 2011. May: 140(6): 1756- 1767. 42. Sun X, Chen XB, Hu SF. Detection of serum immunoglobulins in pulmonary ascariasis patients. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi.1990;8(2):131-3. 43. Tu L, Chen J, Zhang H, Duan L. Interleukin-4 Inhibits Regulatory T Cell Differentiation through Regulating CD103+ Dendritic Cells. Front Immunol. 2017 Mar 3;8:214. doi: 10.3389/fimmu.2017.00214. eCollection 2017. 44. Wang X., Yang, Y. Huycke M. Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect. Gut. 2015 Mar; 64(3): 459–468. 45. Wenjie Y, Yi L, Wei X, Le D, Xiaoting L, Weiru J, Xu S, Liang Z, Jie L. The expression characteristics of IL-2, IL-4, IL-17 and IL-10 and the relationships between these cytokines and the severity of ulcerative colitis. FudanXuebao. 2012;39(5):454–459 46. Wehkamp J., Stange E.F., Recent advances and emerging therapies in the non-surgical management of ulcerative colitis. Version 1. F1000Res. 2018; 7: F1000 Faculty Rev-1207. Published online 2018 Aug 7 47. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol. 2007 Mar;81(3):584-92
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