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The aim of the study was to study the possible pathogenetic mechanisms of the formation of bronchial hyperreactivity in bronchial asthma associated with microelementoses. The study group consisted of 45 children with bronchial asthma. The research methods were the method of neutron activation analysis of the content of trace elements in hair and the method of atomic absorption spectrometry of blood serum. The state of bronchial hyperreactivity was accompanied by a deficiency of essential microelements (69.6%) in severe bronchial asthma, against the background of selenium and zinc deficiency (plasma levels below 0.2 and 0.35 mg/l, respectively), and a decrease in the speed parameters of the function of external respiration.

  • O'qishlar soni175
  • Nashr sanasi06-10-2022
  • Asosiy tilIngliz
  • Sahifalar21-24
English

The aim of the study was to study the possible pathogenetic mechanisms of the formation of bronchial hyperreactivity in bronchial asthma associated with microelementoses. The study group consisted of 45 children with bronchial asthma. The research methods were the method of neutron activation analysis of the content of trace elements in hair and the method of atomic absorption spectrometry of blood serum. The state of bronchial hyperreactivity was accompanied by a deficiency of essential microelements (69.6%) in severe bronchial asthma, against the background of selenium and zinc deficiency (plasma levels below 0.2 and 0.35 mg/l, respectively), and a decrease in the speed parameters of the function of external respiration.

Muallifning F.I.Sh. Lavozimi Tashkilot nomi
1 Karimova N.I. PhD, doctoral student of the department of pulmonology Republican Specialized Scientific and Practical Medical Center of Pediatrics
2 Shamsiev F.M. Doctor of Medical Sciences, Professor, Head of the Department of Pulmonology Republican Specialized Scientific and Practical Medical Center of Pediatrics
3 Abdullaev S.K. basic doctoral student of the Department of Children's Diseases №1 Tashkent Medical Academy
Havola nomi
1 1. Chernyak B.A., Vorzheva I.I., Sukmanskaya E.O. Asthma. - 2020. - Vol. 1 (31). — pp. 69–77. 2. Koh Y. Y. Bronchial hyperresponsiveness in adolescents with long-term asthma remission: importance of a Family history of bronchial hyperresponsiveness / Y. Y. Koh, E. K. Kang, H. Kang // Chest. - 2015. - Vol. 124, No. 3. - P. 819-825. 3. Molokova A. V. Clinical and pathogenetic aspects of hyperreactivity of the bronchial tree in children with atopic dermatitis in combination with bronchial asthma: author. dis. ... Dr. med. Sciences / A. V. Molokova. - Novosibirsk, 2014. - 36 p. 5. Pavlenko N. S. Clinical, immunological and metabolic features of atopic dermatitis in children with selenium and zinc deficiency: author. dis. ... cand. honey. Sciences / N. S. Pavlenko. - Novosibirsk, 2021. - 21 p. 6. Mineral homeostasis and respiratory disorders in children with bronchial asthma / T. G. Reshetova [et al.] // Pulmonology of childhood: problems and solutions, no. 2. - Moscow-Ivanovo, 2020. - P. 140–142. 7. Barbarino F. Zinc and T-lymphocyte subsets in patients with pulmonary diseases / F. Barbarino, E. Toganel, A. Cocarla // Trace Elements in Man and Animals - TEMA - 8 / Eds. M. Anke, D. Meissner, C. F. Mils. - Dresden, 1993. - P. 890-891. 8. Beasley R. Selenium, glutathione peroxidase and asthma / R. Beasley // Clin. Exp. Allergy. - 1991. - P. 157-159 9. Richter M. Zinc status modulates bronchopulmonary eosinophil infiltration in a murine model of allergic inflammation / M. Richter, R. Bonneau, M. A. Girard // Chest. - 2018. - Vol. 123 (3 Suppl). — P. 446. 10. Vural H. Concentrations of copper, zinc and various elements in serum of patients with bronchial asthma / H. Vural, K. Uzun, E. Uz // J. Trace Elem. Med. Biol. - 2020. - Vol. 14(2). — P. 88–91. 11. Immunopharmacology of trace elements / A. V. Kudrin [et al.]. - M. : KMK Publishing House, 2020. - 537 p. 12. Rustembekova S. A. Microelementoses and environmental risk factors / S. A. Rustembekova, T. A. Baraboshkina. — M.: Logos, 2016. — 196 p. 13. Boulet L. P. Physiopathology of airway hyperresponsiveness / L. P. Boulet // Curr. Allergy Asthma Rep. - 2013. - Vol. 3, No. 2. — P. 166–171. 14. Standardization of tests for the study of pulmonary function / A. G. Chuchalin [et al.]. — M.: Pulmonology, 1993. — S. 60–86.
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