27

Considerable evidence suggests that endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is primarily expressed in endocrine glands and certain endocrine-dependent organs. Numerous studies indicate that EG-VEGF promotes angiogenesis and cell proliferation, despite its classification outside the VEGF family. While ample data exist regarding the involvement of this growth factor in normal developmental processes, conflicting findings have emerged regarding its role in pathological conditions, particularly malignant tumors. Therefore, our current paper aims to explore the function of EG-VEGF in both normal tissues and various malignant tumors, shedding light on its impact on angiogenic processes

  • O'qishlar soni 27
  • Nashr sanasi 01-05-2024
  • Asosiy tilIngliz
  • Sahifalar121-135
English

Considerable evidence suggests that endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is primarily expressed in endocrine glands and certain endocrine-dependent organs. Numerous studies indicate that EG-VEGF promotes angiogenesis and cell proliferation, despite its classification outside the VEGF family. While ample data exist regarding the involvement of this growth factor in normal developmental processes, conflicting findings have emerged regarding its role in pathological conditions, particularly malignant tumors. Therefore, our current paper aims to explore the function of EG-VEGF in both normal tissues and various malignant tumors, shedding light on its impact on angiogenic processes

Muallifning F.I.Sh. Lavozimi Tashkilot nomi
1 Rajabov .M. teacher Alfraganus” University
Havola nomi
1 1.Li M., Bullock C. M., Knauer D. J., Ehlert F. J., Zhou Q. Y. Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle.Molecular Pharmacology.2001;59(4):692–698.[PubMed][Google Scholar]2.Battersby S., Critchley H., Morgan K., Millar R., Jabbour H. Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.The Journal of Clinical Endocrinology and Metabolism.2004;89(5):2463–2469. doi:10.1210/jc.2003-032012.[PubMed] [CrossRef][Google Scholar]3.Fraser H. M., Bell J., Wilson H., et al. Localization and quantification of cyclic changes in the expression of endocrine gland vascular endothelial growth factor in the human corpus luteum.The Journal of Clinical Endocrinology and Metabolism.2005;90(1):427–434. doi:10.1210/jc.2004-0843.[PubMed] [CrossRef][Google Scholar]4.Hoffmann P., Feige J. J., Alfaidy N. Expression and oxygen regulation of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 and its receptors in human placenta during early pregnancy.Endocrinology.2006;147(4):1675–1684. doi:10.1210/en.2005-0912.[PubMed] [CrossRef][Google Scholar]5.Hoffmann P., Feige J. J., AlfaidyN. Placental expression of EG-VEGF and its receptors PKR1(prokineticin receptor-1) and PKR2 throughout mouse gestation.Placenta.2007;28(10):1049–1058. doi:10.1016/j.placenta.2007.03.008.[PubMed][CrossRef][Google Scholar]6.Kisliouk T., Levy N., Hurwitz A., Meidan R. Presence and regulation of endocrine gland vascular endothelial growth factor/prokineticin-1 and its receptors in ovarian cells.The Journal of Clinical Endocrinology and Metabolism.2003;88(8):3700–3707. doi:10.1210/jc.2003-030492.[PubMed] [CrossRef][Google Scholar]7.Kisliouk T., Podlovni H., Meidan R. Unique expression and regulatory mechanisms of EG-VEGF/prokineticin-1 and its receptors in the corpus luteum.Annals of Anatomy.2005;187(5–6):529–537. doi:10.1016/j.aanat.2005.07.005.[PubMed] [CrossRef][Google Scholar]8.LeCouter J., Kowalski J., Foster J., et al. Identification of an angiogenic mitogen selective for endocrine gland endothelium.Nature.2001;412(6850):877–884. doi:10.1038/35091000.[PubMed] [CrossRef][Google Scholar]9.Samson M., Peale F. V., Frantz G., Rioux-Leclercq N., De Meyts E. R., Ferrara N. Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumor suggests roles in normal and pathological testis angiogenesis.The Journal of Clinical Endocrinology and Metabolism.2004;89(8):4078–4088. doi:10.1210/jc.2003-032024.[PubMed] [CrossRef][Google Scholar]10.Mollay C., Wechselberger C., Mignogna G., et al. Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats.European Journal of Pharmacology.1999;374(2):189–196. doi:10.1016/S0014-2999(99)00229-0.[PubMed] [CrossRef][Google Scholar]11.Wechselberger C., Puglisi R., Engel E., Lepperdinger G., Boitani C., Kreil G. Bv8, a small protein from frog skin and its homologue from snake venom induce hyperalgesia in rats.FEBS Letters.1999;462(1–2):177–181. doi:10.1016/S0014-5793(99)01473-8.[PubMed] [CrossRef][Google Scholar]12.Alfaidy N., Hoffmann P., Boufettal H., et al. The multiple roles of EG-VEGF/PROK1 in normal and pathological placental angiogenesis.BioMed Research International.2014;2014:p. 10. doi:10.1155/2014/451906.451906[PMC free article][PubMed] [CrossRef][Google Scholar]13.Ferrara N., Frantz G., LeCouter J., et al. Differential expressionof the angiogenic factor genes VEGF and EG-VEGF in normal and polycistic human ovaries.The American Journal of Pathology.2003;162(6):1881–1893. doi:10.1016/S0002-9440(10)64322-2.[PMC free article][PubMed] [CrossRef][Google Scholar]14.Su M. T., Huang J. Y., Tsai H. L., Chen Y. C., Kuo P. L. A common variant of PROK1 (V67I) acts as a genetic modifier in early human pregnancy through down-regulation of gene expression.International Journal of Molecular Sciences.2016;17(2):162. doi:10.3390/ijms17020162.[PMC free article][PubMed] [CrossRef][Google Scholar]15.Su M. T., Lin S. H., Chen Y. C., Kuo P. L. Gene-gene interactions and gene polymorphisms of VEGFA and EG-VEGF gene systems in recurrent pregnancy loss.Journal of Assisted Reproduction and Genetics.2014;31(6):699–705. doi:10.1007/s10815-014-0223-2.[PMC free article][PubMed] [CrossRef][Google Scholar]16.LeCouter J., Lin R., Ferrara N. Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis.Nature Medicine.2002;8(9):913–917. doi:10.1038/nm0902-913.[PubMed] [CrossRef][Google Scholar]17.Aravind L., Koonin E. V. A colipase fold in the carboxy-terminal domain of the Wnt antagonists–the Dickkopfs.Current Biology.1998;8(14):477–478. doi:10.1016/S0960-9822(98)70309-4.[PubMed] [CrossRef][Google Scholar]18.Glinka A., Wu W., Delius H., Monaghan A. P., Blumenstock C., Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.Nature.1998;391(6665):357–362. doi:10.1038/34848.[PubMed] [CrossRef][Google Scholar]19.Esser S., Wolburg K., Wolburg H., Breier R. G., Kurzchaliant T., Risau W. Vascular endothelial growth factor induces endothelial fenestrations in vitro.The Journal of Cell Biology.1998;140(4):947–859. doi:10.1083/jcb.140.4.947.[PMC free article][PubMed] [CrossRef][Google Scholar]20.LeCouter J., Kowalski J., Foster J., et al. Identification of an angiogenic mitogen selective for endocrine gland endothelium.Nature.2001;412(6850):877–884. doi:10.1038/35091000.[PubMed] [CrossRef][Google Scholar]
Kutilmoqda