In this study, with the participation of such complex catalytic systems as 3,3'-Ph2BINOL-2Li/Ti(OiPr)4/Et2Zn and Zn(OTf)2/TBAF•3H2O, some ketones with a carbonyl group in the molecule -cyclopentanone, cyclohexanone, camphor , adamantanone, methyl butyl ketone, methyl ethyl ketone, methyl isopropyl ketone, methyl tert-butyl ketone, acetophenone, methyl p-tolyl ketone, methyl mesityl ketone, methyl β-naphthyl ketone, methyl furyl ketone, methyl thienyl ketone,methyl pyridinyl ketone and methyl 2-chlorothiophenyl ketone terminal alkynes –acetylene, hexine, octine and phenylacetylene by alkynylation reaction acetylene alcohols with high biological activity were synthesized. The relative efficiency of acetylenicalcohols synthesis was established based on the structure, nature, and chemical activity of ketone molecules, the nucleophilic addition reaction of ketones, and their influence on the product yield. The process of synthesizing acetylenic alcohols in selected systems and the factors affecting the reaction, such as temperature, reaction duration, catalyst, promoter and solvent nature, quantities of reagents and substrates, types and quantities of intermediate and by-products, were systematically studied and analyzed based on the obtained results. The activation energies of the performed reactions were determined, and the kinetics of chemical changes were analyzed. The efficiency, selectivity, and stability of catalytic systems were determined, and a relative catalytic efficiency sequence was proposed based on their influence on the reaction and product yield. The purity and structure of the synthesized compounds were investigated using modern physical and chemical research methods, specific constants were determined, and energetic and quantum chemical characteristics were calculated, including the charges of atoms in the molecules, electron density, and optical properties. The synthesized acetylenic alcohols were also applied in practice as components for anti-foaming agents in oil and gas industries and as inhibitors for complexation of heavy metals in natural gas compositions.
In this study, with the participation of such complex catalytic systems as 3,3'-Ph2BINOL-2Li/Ti(OiPr)4/Et2Zn and Zn(OTf)2/TBAF•3H2O, some ketones with a carbonyl group in the molecule -cyclopentanone, cyclohexanone, camphor , adamantanone, methyl butyl ketone, methyl ethyl ketone, methyl isopropyl ketone, methyl tert-butyl ketone, acetophenone, methyl p-tolyl ketone, methyl mesityl ketone, methyl β-naphthyl ketone, methyl furyl ketone, methyl thienyl ketone,methyl pyridinyl ketone and methyl 2-chlorothiophenyl ketone terminal alkynes –acetylene, hexine, octine and phenylacetylene by alkynylation reaction acetylene alcohols with high biological activity were synthesized. The relative efficiency of acetylenicalcohols synthesis was established based on the structure, nature, and chemical activity of ketone molecules, the nucleophilic addition reaction of ketones, and their influence on the product yield. The process of synthesizing acetylenic alcohols in selected systems and the factors affecting the reaction, such as temperature, reaction duration, catalyst, promoter and solvent nature, quantities of reagents and substrates, types and quantities of intermediate and by-products, were systematically studied and analyzed based on the obtained results. The activation energies of the performed reactions were determined, and the kinetics of chemical changes were analyzed. The efficiency, selectivity, and stability of catalytic systems were determined, and a relative catalytic efficiency sequence was proposed based on their influence on the reaction and product yield. The purity and structure of the synthesized compounds were investigated using modern physical and chemical research methods, specific constants were determined, and energetic and quantum chemical characteristics were calculated, including the charges of atoms in the molecules, electron density, and optical properties. The synthesized acetylenic alcohols were also applied in practice as components for anti-foaming agents in oil and gas industries and as inhibitors for complexation of heavy metals in natural gas compositions.
| № | Muallifning F.I.Sh. | Lavozimi | Tashkilot nomi |
|---|---|---|---|
| 1 | Ziyadullayev O.. | Doctor of Chemistry, | Chirchiq State Pedagogical University |
| 2 | Otamukhamedova G.. | Doctorof Philosophy | Chirchiq State Pedagogical University |
| № | Havola nomi |
|---|---|
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