The article is devoted to the problems associated with connective tissue dysplasia (CTD), predominantly undifferentiated forms of the disease (nDST). The topic's relevance is due to the high prevalence of this pathological condition. The generalized nature of connective tissue damage with the involvement of the reproductive system in the pathological process significantly affects the course of pregnancy and Birth. Complications that may be associated with pregnancy, childbirth, and the postpartum period in women with nDST and which cause a high need for surgical aids: amnio-, episio-and perineotomy, andcesarean section are presented. Particular attention is paid to magnesium, which plays one of the determining roles in the complex biosynthesis of the extracellular matrix in the formation of connective tissue and the morphofunctional state of fibroblasts. The methods used to detect connective tissue metabolism disorders (determination of the level of oxyproline and fibronectin in blood serum, pyrinx D and glucosaminoglycans in urine, etc.) are described. Given the lack of reliable diagnostic (biochemical and genetic) criteria for nDST, special attention is paid to the need for an integrated approach to assessing the condition of patients using anamnesis data, andthe results of clinical, instrumental, and laboratory examinations.
The article is devoted to the problems associated with connective tissue dysplasia (CTD), predominantly undifferentiated forms of the disease (nDST). The topic's relevance is due to the high prevalence of this pathological condition. The generalized nature of connective tissue damage with the involvement of the reproductive system in the pathological process significantly affects the course of pregnancy and Birth. Complications that may be associated with pregnancy, childbirth, and the postpartum period in women with nDST and which cause a high need for surgical aids: amnio-, episio-and perineotomy, andcesarean section are presented. Particular attention is paid to magnesium, which plays one of the determining roles in the complex biosynthesis of the extracellular matrix in the formation of connective tissue and the morphofunctional state of fibroblasts. The methods used to detect connective tissue metabolism disorders (determination of the level of oxyproline and fibronectin in blood serum, pyrinx D and glucosaminoglycans in urine, etc.) are described. Given the lack of reliable diagnostic (biochemical and genetic) criteria for nDST, special attention is paid to the need for an integrated approach to assessing the condition of patients using anamnesis data, andthe results of clinical, instrumental, and laboratory examinations.
| № | Muallifning F.I.Sh. | Lavozimi | Tashkilot nomi |
|---|---|---|---|
| 1 | Khudoyarova . . | Professor | ! |
| 2 | Shodikulova G.Z. | Professor | ! |
| 3 | Yunusova Z.M. | Assistant | ! |
| № | Havola nomi |
|---|---|
| 1 | Ilyina I.Yu., Dobrokhotova Yu.E., Zhdanova M.S. Influence of dysplasia of connective tissue on the development of genital prolapse. Russian Bulletin of Obstetrician-Gynecologist. 2009; 9(4):15–18. Nechaeva G.I., Viktorova I.A. Dysplasia of connective tissue: terminology, diagnosis, tactics of patient management. Omsk: BLANKOM; 2007. National recommendations of the Russian Scientific Medical Society of Therapists for the diagnosis, treatment and rehabilitation of patients with connective tissue dysplasia. Medical Bulletin of the North Caucasus. 2016; 11(1):2–76. DOI: 10.14300/mnnc.2016.11001. Smolnova T.Yu., Adamyan L.V. Dynamics of phenotypic signs of connective tissue dysplasia syndrome in different age periods. Relevance of the problem in obstetrics and gynecology. Obstetrics and Gynecology. 2013; 4:74–79. Ilyina I.Yu., Dobrokhotova Yu.E., Zhdanova M.S. Optimisation of treatment methods aimed at improving collagen formation processes in women with connective tissue dysplasia. Vestnik RUDN University. Medicine. 2009; 5:76–82. I. Gazit Y., Jacob G., Grahame R. Ehlers-Danlos Syndrome-Hypermobility Type: A Much Neglected Multisystemic Disorder. Rambam Maimonides Med J. 2016; 7(4).e0034. DOI: 10.5041/RMMJ.10261. Kiss J., Balla B., Kosa J.P. et al. Gene expression patterns in the bone tissue of women with fibrous dysplasia. Am J Med Genet A. 2010; 152A (9):2211–2020. DOI: 10.1002/ajmg.a.33559. Zoloto E.V. Dysplasia connective tissue — a problem in modern medicine. University Hospital. 2018; 4(29):109–116. Nechaeva G.I., Yakovlev V.M., Konev V.P., et al. Dysplasia connective tissue: basic clinical syndromes, formulation of diagnosis, treatment. Attending physician. 2008; 2:22–28. Torshin I.Yu., Gromova O.A. Dysplasia of connective tissue, cellular biology and molecular mechanisms of magnesium impact. RMJ. 2008; 16(4):230. Boudin E., van Hul W. Sclerosing bone dysplasias. Best Pract Res Clin Endocrinol Metab. 2018; 32(5):707–723. DOI: 10.1016/j.beem.2018.06.003. Martins K.F., Jarmy-DiBella Z.I., Fonseca A.M. et al. Evaluation of demographic, clinical characteristics and genetic polymorphism as risk factors for pelvic organ prolapse in Brazilian women. Neurourol Urodynam. 2011; 30:1325–1328. Perumal R.K., Perumal S., Thangam R. et al. Ollagen-fucoidan blend film with the potential to induce fibroblast proliferation for regenerative applications. Int J Biol Macromol. 2018; 106:1032–1040. Druk I.V., Rozhdestvenskiy A.S., Smyalovsky D.V., et al. Cerebral vascular syndrome dysplasia of connective tissue as a cause of subarachnoid hemorrhages in patients of young age. S.S. Korsakov Journal of Neurology and Psychiatry. 2018; 118(12–2):15–22. DOI: 10.17116/jnevro201811812215. Forlino A., Marini J.C. Osteogenesis imperfecta. Lancet. 2016; 387(10028):1657–1671. DOI: 10.1016/S0140-6736 (15) 00728-X. Marini J.C., Forlino A., Bächinger H.P. et al. Osteogenesis imperfecta. Nat Rev Dis Primers. 2017; 18(3):17052. DOI: 10.1038/nrdp.2017.52. Meester J.N., Verstraeten A., Schepers D. et al. Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome. Ann Cardiothorac Surg. 2017; 6(6):582–594. DOI: 10.21037/acs.2017.11.03. Veropotvelyan P.N., Tsekhmistrenko I.S., Veropotvelyan N.P., Gatselyuk S.V. Strategicheskiy vzglyad na faktory riska prolapsa genitalia i sposoby ikh korrektsii [Strategic view on risk factors of genital prolapse and methods of their correction]. Medical aspects of women's health. 2016; 3(100):66–74. Shcherbinina N.A., Alaya Lamia. Risk factors for genital prolapse in perimenopausal women with connective tissue dysplasia and their correction. Bulletin of Problems of Biology and Medicine. 2016; 2(128):135–139. Garcia-González M., Rodríguez-Lozano B., Bustabad S., Ferraz-Amaro I. Undifferentiated connective tissue disease: predictors of evolution into defi nitedisease. Clin Exp Rheumatol. 2017; 35(5):739–745. Khodzhaeva Z.S., Gurbanova S.R. Clinical and pathogenetic justification of the use of magnesium preparations in pregnant women with isthmic-cervical insufficiency and undifferentiated dysplasia of connective tissue. Obstetrics and Gynecology. 2011; 3:57–63. Shilov A.M., Melnik M.V., Sviridova A.Y. Dysplasia of connective tissue and magnesium deficiency. Pharmateca. 2010; 20:35–38. Barbagallo M., Belvedere M., Dominguez L.J. Magnesium homeostasis and aging. Magnesium Research. 2009; 22(4):235–246. Shankar H., Kumar N., Sandhir R. et al. Association of dietary intake below recommendations and micronutrient deficiencies during pregnancy and low birthweight. J Perinat Med. 2019; 47(7):724–731. DOI: 10.1515/jpm-2019-0053. Wallace E., Lowry J., Smith S.M., Fahey T. The epidemiology of malpractice claims in primary care: a systematic review. BMJ Open. 2013; 3(7): e002929. DOI: 10.1136/bmjopen-2013-002929. Chaika V.K., Zheleznaya A.A., Luneva N.N. Management of complicated pregnancy in pregnant women with undifferentiated dysplasia of connective tissue (clinical case). Medical and social problems of the family. 2019; 24(1):104–111. Eltayeb R., Rayis D.A., Sharif M.E. et al. The prevalence of serum magnesium and iron deficiency anaemia among Sudanese women in early pregnancy: a cross-sectional study. Trans R Soc Trop Med Hyg. 2019; 113(1):31–35. DOI: 10.1093/trstmh/try109. Gracheva O.N., Gromova O.A. Dysplasia of connective tissue during pregnancy: phenomenology, etiology, magnesium deficiency and molecular mechanisms. Moscow: Miklos; 2012.29 Zhabchenko I.A., Oleshko V.F. Features of the course of pregnancy and childbirth, the state of the fetus and newborn in women with disorders of the obturation function of the cervix during gestation. Protection of motherhood and childhood. 2016; 1(27):5–9. Zheleznaya A.A., Vustenko V.V., Mezhova O.K. Znachenie undifferentiated dysplasia connective tissue in obstetrics and gynecology practice. Medical and social problems of the family. 2015; 20(3–4):55–57. Anastasyeva V.G., Trunchenko N.V. Osobennosti techeniya pregnancii i otkhoda rodov u pregnannykh s prolapsom mitral'nogo valvea [Features of the course of pregnancy and the outcome of childbirth in pregnant women with mitral valve prolapse]. Bulletin of the East-Siberian Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences. 2007; 3(55):18–22. Manuck T.A. The genomics of prematurity in an era of more precise clinical phenotyping: a review. Semin Fetal Neonatal Med. 2016; 21(2):89–93. DOI: 10.1016/j.siny.2016.01.001. Vink J., Feltovich H. Cervical etiology of spontaneous preterm birth. Semin Fetal Neonatal Med. 2016; 21(2):106–112. DOI: 10.1016/j.siny.2015.12.009. Komissarova L.M., Karachaeva A.N., Kesova M.I. Course of pregnancy and childbirth in dysplasia of connective tissue. Obstetrics and Gynecology. 2012; 3:4–8. Kan N.E., Tyutyunnik V.L., Amiraslanov E.Yu., et al. Obstetric complications and undifferentiated dysplasia of connective tissue. Clinical and Experimental Surgery. Journal named after Acad. B.V. Petrovsky. 2015; 2:47–52. Kerimkulova N.V., Nikiforova N.V., Torshin I.Yu., et al. Pregnancy and childbirth in women with dysplasia of connective tissue and iron deficiency anemia. Issues of Gynecology, Obstetrics and Perinatology. 2014; 13(5):11–21. Kononenko I.S., Zhukova N.P. Genetic predictors of isthmic-cervical insufficiency. Russian Bulletin of Obstetrician-Gynecologist. 2020; 20(2):29–34. DOI: 10.17116/rosakush20202002129. Kravchenko E.N., Tyshkevich O.S. Diagnostika undifferentiated forms dysplasia connective tissue [Diagnostics of undifferentiated forms of dysplasia of connective tissue]. Vesti MANEB in the Omsk region. 2014; 1(4):4–7. Kerchelaeva S.B., Kuznetsova O.V., Burdenko M.V., et al. Pathology of the Heart and Pregnancy: Textbook. Moscow; 2018:9–43. Kudinova E.G. Correction of changes in the system of hemostasis in pregnant women with hereditary disorders of connective tissue with the use of vitamin-mineral complexes. RMJ. Mother and Child. 2014; 22(19):1406–1411. Vagelli R., Tani C., Mosca M. Pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Practical messages from the EULAR guidelines. Pol Arch Intern Med. 2017; 127(2):115–121. DOI: 10.20452/pamw.3906. Watson S.P., Lowe G.C., Lordkipanidzé M., Morgan N.V. GAPP consortium. Genotyping and phenotyping of platelet function disorders. J. Thromb Haemost. 2013; 11(Suppl. 1):351–363. DOI: 10.1111/jth.12199. Stevens D.U., Al-Nasiry S., Bulten J., Spaanderman M.E.A. Decidual vasculopathy in preeclampsia: lesion characteristics relate to disease severity and perinatal outcome. Placenta. 2013; 34(9):805–809. DOI: 10.1016/j.placenta.2013.05.008. Smetnik V.P. Meditsina klimacteriya [Medicine of climactery]. Moscow: Litera; 2006.45 . Tarabanova O.V., Krutova V.A., Ordokova A.A., et al. Laboratory and immunohistochemical predictors of genital prolapse recurrence. Sechenov Bulletin. 2017; 4(30):42–50. Fadeeva T.S. Biokhimicheskie i klinicheskie proyavleniya dysplasia connective tissue u zhenshchina s opolozheniyami i vydropaniami vnutrennykh polovykh organov [Biochemical and clinical manifestations of dysplasia of connective tissue in women with omissions and drops of internal sexual organs]. Education and Science in Modern Conditions. 2016; 2–1 (7):61–62. Joosten M.M., Gansevoort R.T., Mukamal K.J. et al. PREVEND Study Group. Urinary magnesium excretion and risk of hypertension: the prevention of renal and vascular end-stage disease study. Hypertension. 2013; 61(6):1161–1167. DOI: 10.1161/HYPERTENSIONAHA.113.01333. Karakov K.G., Elbekyan K.S., Markarova G.V. Osnovy biokhimii tissues i organov polnosti orta: uchebnoe posobie [Fundamentals of biochemistry of tissues and organs of oral cavity: textbook]. Stavropol; 2012. Henkin R.I., Gouliouk V., Fordyce A. Distinguishing patients with glossopyrosis from those with oropyrosis based upon clinical differences and differences in saliva and erythrocyte magnesium. Arch. Oral Biol. 2012; 57(2):205–210. DOI: 10.1016/j.archoralbio.2011.08.010. Kalinin R.E., Suchkov I.A., Pshennikov A.S., et al. Concentration of matrix metalloproteinases and magnesium ions in varicose veins of lower limbs. Angiology and Vascular Surgery. 2016; 22(4):24–28 |