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SYNTHESIS OF 4- (4- (R-OXYMETHYL) -1-Н-1,2,3-TRIAZOL -1-YL) BENZOIC ACIDS AND THEIR POTASSIUM SALTS

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Ўзбекистон кимё журнали

Ўзбекистон кимё журнали

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Background. On the basis of propargyl ester of saturated monocarboxylic acid and paraazidobenzoic acid, 1,2,3-triazole derivatives were synthesized by 1,3-bipolar cycloaddition. Was obtained water-soluble forms of these triazoles - potassium salts. The structure of the synthesized substances was confirmed by modern physical research methods. Initial trials have begun to investigate the pharmacological activity of water-soluble potassium salts. Purpose. Synthesis of 4- (4- (R-hydroxymethyl) 1H-1,2,3-triazol-1-yl) benzoic acid derivatives in the presence of a Cu2I2 catalyst on a 1,3-bipolar cycloaddition. Carrying out the synthesis of the watersoluble form of the obtained substances - to synthesize potassium salts. Analyze the structure of the synthesized compounds by physical research research methods. Methodology: 4- (4- (R-hydroxymethyl) 1H-1,2,3-triazol-1-yl) benzoic acids were synthesized by the reaction of 1,3-bipolar cycloaddition of propargyl ester of a monobasic saturated carboxylic acid and para-azidobenzoic acid. The potassium salts of the corresponding substances were obtained. The structure of the synthesized substances was confirmed by the analysis of IR-, 1H NMR and Mass spectrometry data. Originality. Derivatives of 1,2,3-triazole were obtained on the basis of propargyl ethers of monobasic saturated low-molecular-weight monocarboxylic acids. For the first time, water-soluble forms of 4- (4- (R-hydroxymethyl) -1H-1,2,3-triazol-1-yl) benzoic acid its potassium salts were synthesized. The factors acting on the course of the reaction were studied. Findings: 4- (4- (R-hydroxymethyl) -1H-1,2,3-triazol-1-yl) benzoic acids and their potassium salts were synthesized in the presence of KOH. The good water solubility of their potassium salts has been confirmed. The structure was analyzed and confirmed by IR, 1H NMR and Mass spectrometry.Highlights: - 4- (4- (substituted) 1H-1.2.3-triazol-1-yl) benzoic acids were synthesized; - based on the synthesized triazoles, their potassium salts were obtained; - the obtained salts possess good water solubility; - effect of temperature and nature of the solvent on the reaction yield.

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# 2# 1# реакция 1# калиевые соли4-(4-(R-оксиметил)-# 3-триазол-1-ил) бензойной кислот# 3-биполярного циклоприсоединения# 4-(4-(пентаноилоксиметил)-1Н-1# 3триазол-1-ил) бензойная кислота# калиевая соль 4-(4-(ацетоксимети# 4-(4-(R-оксиметил)-1Н-1# 3-триазол-1-ил) бензой кислота к# 3-биполяр циклобирикиш  реакцияс# 3-триазол-1-ил)бензой кислота# 4-(4-(ацетоксиметил)-1Н-1# potassium salts of 4- (4- (R-hyd# 3-triazol-1-yl) benzoic acid# 3bipolar cycloaddition reaction# 4- (4- (pentanoyloxymethyl) -1Н# potassium salt of 4- (4- (acetox

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