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SYNTHESIS, COMPOSITION AND SOME PHYSICAL AND CHEMICAL PROPERTIES OF SUPRAMOLECULAR COMPLEXES OF GLYCYRRHIZIC ACID

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Background. Many poorly soluble or even water-insoluble drug substances (aspirin, indomethacin, gossypol, ragosin, etc.) dissolve well in water in the presence of even a small amount of glycyrrhizic acid (GA). Purpose. The aim of the study is to modify the previously synthesized drug megosin with the monoammonium salt of glycyrrhizic acid (MASGC) and to investigate physical-chemical properties of the obtained supramolecular complexes. Methodology. For investigation of the individuality and structure of the synthesized supramolecular complexes of megosin with MASGC, such methods as UV, IR and PMR spectroscopy were applied as well as the study of fine structure of supramolecular complexes was performed on an electron microscope REM200. Originality. For the first time the composition and fine structure of the obtained supramolecular complexes of megosin with MASGC (in ratios 1: 1, 1: 2 and 1: 4) were investigated by electron microscopic method. Findings. On the basis of the obtained theoretical and experimental investigations, the conditions for the preparation of the supramolecular complex of the monoammonium salt of glycyrrhizic acid (MASGC) for the drug Megosin were determined and thus it was found out that water solubility of the drug had been increased by an order. A TLC method has been elaborated for a new medicinal substance and the optimal system of organic solvents has been chosen for the separation of it’s constituents. Highlights: - supramolecular complexes of the drug «Megosin» with MASGC (ratio 1:1, 1:2; 1:4); - the composition and fine structure of the obtained complexes were investigated.

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# спектроскопия# глицирризин кислотаси# глицирризиновая кислота# glycyrrhizic acid# «хозяин–гость»# полидентантный лиганд# низкодозные лекарственные субста# “мезбон-меҳмон”# полидентант лиганд# кичик дозали доривор субтанцияла# спектроскопия.# «host – guest»# supramolecular complex# bioavailability of drugs# polydentate ligand# pharmacon# low-dose drug substances# spectroscopy.

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https://eroi.uz/11.0030/A0220-0068

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