Ushbu tahliliy maqolada turli adabiyot ma’lumotlari asosida hozirgi kunda tibbiyot amaliyotida qo‘llanilib kelinayotgan va so‘nggi yillarda klinik oldi tekshiruvlar bosqichidagi 1,2,4-triazol hosilalarining turli xil neyropsixotrop faolliklari haqidagi ma’lumotlar umumlashtirilgan. Biologik faolliklarini
ularning strukturaga va ta’sir mexanizmlarini turli xil mediator hamda ion kanallariga bog‘liqligi asoslantirilgan. turli xil mediator hamda ion kanallariga bog‘liqligi asoslantirilgan.
This review article summarizes data from various literature on the various neuropsychotropic activity of 1,2,4-triazole derivatives, which are currently used in medical practice and in recent years are at the stage of preclinical studies. The dependence of their biological activity on the structure and
mechanisms of action of various mediators and ion channels is substantiated.
Ushbu tahliliy maqolada turli adabiyot ma’lumotlari asosida hozirgi kunda tibbiyot amaliyotida qo‘llanilib kelinayotgan va so‘nggi yillarda klinik oldi tekshiruvlar bosqichidagi 1,2,4-triazol hosilalarining turli xil neyropsixotrop faolliklari haqidagi ma’lumotlar umumlashtirilgan. Biologik faolliklarini
ularning strukturaga va ta’sir mexanizmlarini turli xil mediator hamda ion kanallariga bog‘liqligi asoslantirilgan. turli xil mediator hamda ion kanallariga bog‘liqligi asoslantirilgan.
This review article summarizes data from various literature on the various neuropsychotropic activity of 1,2,4-triazole derivatives, which are currently used in medical practice and in recent years are at the stage of preclinical studies. The dependence of their biological activity on the structure and
mechanisms of action of various mediators and ion channels is substantiated.
| № | Muallifning F.I.Sh. | Lavozimi | Tashkilot nomi |
|---|---|---|---|
| 1 | Rahimboev S.. | tadqiqotchi | O‘zRFA O‘simlik moddalari kimyosi instituti Toshkent, O‘zbekiston |
| 2 | Sanoev Z.. | tadqiqotchi | Toshkent davlat stomatologiya instituti, O‘zRFA O‘simlik moddalari kimyosi instituti Toshkent, O‘zbekiston |
| № | Havola nomi |
|---|---|
| 1 | 1. Abdulrasool MM, Jawad AH. Synthesis, Characterization and Evaluation of Biological Activity of New Heterocyclic Compounds Containing 1,2,4- Triazoleand 1,3,4-Thiadiazole Rings. Int. J. App. Sci. Tech, 2 (10), 2012, 155-164. |
| 2 | 2. Alswah M, Ghiaty A. Synthesis and Biological Evaluation of Some [1,2,4] Triazolo[4,3- a] quinoxaline Derivatives as Novel Anticonvulsant Agents. ISRN Org. Chem, 1, 2013, 1 -7. |
| 3 | 3. Amin KM, El-Zahar MI. Synthesis and Anticancer Activity of Novel, Tetralin-6- ylpyridine and Tetralin-6-ylpyrimidine Derivatives. Acta. Polo. Pharm. Drug Res. 66(3), 2009, 279-291. |
| 4 | 1. Baviskara BA, Khadabadi SS. Synthesis of clubbed TriazolylIndeno[1,2- C]Isoquinolines as an Novel Anticancer Agent. Pel. Res. Lib. Pharm. Sin. 3(1), 2012, 24-30. |
| 5 | 5. Bekircan O, Menteşe E, Ülker S. Synthesis of Some New 1,2,4-Triazole Derivatives Starting from 3-(4-Chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol with Anti-Lipase and Anti-Urease Activities. Arch. Pharm. Chem. Life Sci. 347, 2014, 387–397. |
| 6 | 6. Bulut VN, Duran C. A Triazole Derivatives as a New Acid-Base Indicator. Bull. Chem. Soc. Ethiop, 24(3), 2010, 457-460. |
| 7 | 7. Everitt, Hazel; Baldwin, David S; Stuart, Beth; Lipinska, Gosia; Mayers, Andrew; Malizia, Andrea L; Manson, Christopher CF; Wilson, Sue. Antidepressants for insomnia in adults//Cochrane Database of Systematic Reviews. 2018 |
| 8 | 8. Guan LP, Jin QH, Tian GR, Chai KY, Quan ZS. Synthesis of some quinoline-2(1H)- one and 1,2,4-triazolo [4,3-a] quinoline derivatives as potent anticonvulsants. J Pharm Sci 2007; 10:254–262. |
| 9 | 9. Hanif M, Saleem M, Hussain MT, Rama NH, Zaib S, Aslam MAM, Jones PG, Iqbal J. Synthesis, Urease Inhibition, Antioxidant and Antibacterial Studies of Some 4-Amino-5-aryl-3H- 1,2,4-triazole-3-thiones and their 3,6-Disubstituted 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole Derivatives, J. Braz. Chem. Soc, 23 (5), 2012, 854-860. |
| 10 | 10. Hou K, Juan Sun. Synthesis and Antitumor Activity of 1,2,4-Triazoles Having 1,4- Benzodioxan Fragment as a Novel Class of Potent Methionine Aminopeptidase Type Inhibitors. Bio. Med. Chem. 19, 2011, 5948–5954. |
| 11 | 11. Husain A, Naseer MA, Sarafroz M. Synthesis and Anticonvulsant Activity of Some Novel Fused Heterocyclic 1,2,4-Triazolo-[3,4-b]-1,3,4-thaidiazole Derivatives. Acta. Polo. Pharm. Drug Res, 66(2), 2009, 135-140. |
| 12 | 12. Jacob JH, Irshaid FI, Al-Soud YA, Al-Balushi AM, Al-Arqan HR. Synthesis, characterization and evaluation of antibacterial activity of six novel 1,2,4-triazole derivatives against standard and medical bacteria. Adv Stud Biol. 2013;5(6):303–318. |
| 13 | 13. Jufe, GS. New hypnotics: perspectives from sleep physiology// Vertex: journal. — 2007. — Jul-Aug (vol. 18, no. 74) — P. 294—299. |
| 14 | 14. Jürgens, TP; Leone, M. Pearls and pitfalls: neurostimulation in headache (англ.) // Cephalalgia (англ.) рус.. — 2013. — June (vol. 33, no. 8). — P. 512—525. |
| 15 | 15. Kapron, B.; Luszczki, J.J.; Plazinska, A.; Siwek, A.; Karcz, T.; Grybos, A.; Nowak, G.; Makuch-Kocka, A.; Walczak, K.; Langner, E.;et al. Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in- vivo, in-vitro, and in-silico studies. Eur. J. Pharm. Sci. 2019, 129, 42–57. |