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Ushbu maqolada sintetik birikma1-(4 ́-metoksifenil)-6,7-dimetoksi-1,2,3,4-tetragidroizoxinolinkam zaharli sinfga mansub ekanligi, 0.1; 0.5; 1.0; 5.0 va 10.0 mg/kg dozalarda psixo farmakologik faolliklari va tutqanoqqa qarshi solishtirma preparatlar karbamazepin va konvuleksdan qolishmasligi eksperimental tajribalar asosida tasdiqlangan

  • O'qishlar soni 6
  • Nashr sanasi 01-02-2025
  • Asosiy tilO'zbek
  • Sahifalar285-293
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Ushbu maqolada sintetik birikma1-(4 ́-metoksifenil)-6,7-dimetoksi-1,2,3,4-tetragidroizoxinolinkam zaharli sinfga mansub ekanligi, 0.1; 0.5; 1.0; 5.0 va 10.0 mg/kg dozalarda psixo farmakologik faolliklari va tutqanoqqa qarshi solishtirma preparatlar karbamazepin va konvuleksdan qolishmasligi eksperimental tajribalar asosida tasdiqlangan

№ Muallifning F.I.Sh. Lavozimi Tashkilot nomi
1 Sanoyev Z.I. ! Toshkent davlat stomatologiya instituti
№ Havola nomi
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Micheli, “Synthesis and Anticonvulsant Activity of Novel and Potent 2,3-benzodiazepine AMPA/Kainate Receptor Antagonists,” Journal of Medicinal Chemistry, Vol. 42, 1999, pp. 4414-4421.doi:10.1021/jm991086d12.J. J. Luszczki, “Third-Generation Antiepileptic Drugs: Mechanisms of Action, Pharmacokinetics and Interactions,” Pharmacological Reports, Vol. 61, No. 2, 2009, pp. 197-21613.M. L. Barreca, R. Gitto, S. Quartarone, D. L. Luca, G. D. Sarro and A. Chimirri, “Pharmacophore Modeling as an Efficient Tool in the Discovery of Novel Noncompetitive,” Journal of Chemical Information and Modeling, Vol. 43, No. 2, 2003, pp. 651-655. doi:10.1021/ci025625q14.J. F. Howes and C. Bell, “Talampanel,” Neurotherapeutics, Vol. 4, No. 1, 2007, pp. 126-129.doi:10.1016/j.nurt.2006.11.00115.R. Gitto, R. Caruso, V. Orlando, S. Quartarone, M. L. Barreca, G. Ferreri, E. Russo, G. D. Sarro and A. Chimirri, “Synthesis and Anticonvulsant Properties of Tetrahydroisoquinoline Derivative,” Farmaco, Vol. 59, No. 1, 2004, pp. 7-12. doi:10.1016/j.farmac.2003.10.00316.Magdalena Białońet al. 1MeTIQ and olanzapine, despite their neurochemical impact, did not ameliorate performance in fear conditioning and social interaction tests in an MK-801 rat model of schizophrenia. Pharmacol Rep. 2021 Jan 6.doi: 10.1007/s43440-020-00209-9.17.Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Lucyna Antkiewicz-Michaluk. Multiple Administration of Endogenous Amines TIQ and 1MeTIQ Protects Against a 6-OHDA-Induced Essential Fall of Dopamine Release in the Rat Striatum: In Vivo Microdialysis Study. Neurotox Res. 2018 Apr;33(3):523-531.doi: 10.1007/s12640-017-9824-8.Epub 2017 Oct 26.18.Lucyna Antkiewicz-Michaluket al. The mechanism of 1,2,3,4-tetrahydroisoquinolines neuroprotection: the importance of free radicals scavenging properties andinhibition of glutamate-induced excitotoxicity. J Neurochem. doi: 10.1111/j.1471-4159.2006.03756.x.Epub 2006 Mar 3.19.E. Możdżeń et al. 1,2,3,4-Tetrahydroisoquinoline produces an antidepressant-like effect in the forced swim test and chronic mild stress model of depression in the rat: Neurochemical correlates/ European Journal of Pharmacology 729 (2014) 107–11520.E. Możdżeń et al. Antidepressant-like effect of 1,2,3,4-tetrahydroisoquinoline and its methyl derivative in animal models of depression. Pharmacological Reports. PubDate2017-02-08, DOI:10.1016/j.pharep.2017.01.03221.Jurakulov Sh.N., Vinogradova V.I., Levkovich M.G. /Sintez 1-ariltetragidro-izoxinolinovix alkaloidov i ix analogov. //Ximiya prirod. soedin., 2013, s. 62-66.22.Sanoev Z.I., Mirzaev Yu.R. Pharmacological Activity Of The Possessing New Atypical Neuroleptics 1-Phenyltetrahydroisoquinoline Structure. 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