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Мақолада бирламчи лейкоз беморларга диагнозни қўйиш учун биочип технологияларига асосланган молекуляр-генетик маркерлар текширилган. Тадқиқотларда ЎЛ(ўткир лейкоз) дигнози ташхиси билан даволанишни бошлаган 250 нафар беморларни жамлаб ҳисоблаганда 2600 та ген транслокациятаҳлиллари ўрганилди. Уларнинг 13 (26%) тасида химер ген(t(9;22) BCR/ABL p190(7%), t(9;22) BCR/ABL p210(14%), t(10;11) MLL/AF10(7%),t(15;17) PML/RARA bcr-2(14%), t(8;21) AML/ETO(38%), KMT2A (MLL-PTD-9)(7%) та ва KMT2A (MLL-PTD-10) (7%) ДНК молекулалари борлиги аниқланиб тегишли тавсиялар берилган

  • Internet havola
  • DOI10.26739/2181-9300-2018-4-7
  • UzSCI tizimida yaratilgan sana 25-11-2019
  • O'qishlar soni 0
  • Nashr sanasi 19-12-2018
  • Asosiy tilO'zbek
  • Sahifalar41-46
Ўзбек

Мақолада бирламчи лейкоз беморларга диагнозни қўйиш учун биочип технологияларига асосланган молекуляр-генетик маркерлар текширилган. Тадқиқотларда ЎЛ(ўткир лейкоз) дигнози ташхиси билан даволанишни бошлаган 250 нафар беморларни жамлаб ҳисоблаганда 2600 та ген транслокациятаҳлиллари ўрганилди. Уларнинг 13 (26%) тасида химер ген(t(9;22) BCR/ABL p190(7%), t(9;22) BCR/ABL p210(14%), t(10;11) MLL/AF10(7%),t(15;17) PML/RARA bcr-2(14%), t(8;21) AML/ETO(38%), KMT2A (MLL-PTD-9)(7%) та ва KMT2A (MLL-PTD-10) (7%) ДНК молекулалари борлиги аниқланиб тегишли тавсиялар берилган

Русский

В статье рассматриваются молекулярно-генетические исследования маркеровдля диагностики первичного лейкоза на основе технологий биочипов. Исследование включало 2600генных транслокации 250 пациентов с диагнозом острой лейкемии. Из них у 13(26%) выявлен химерный ген(t(9;22) BCR/ABL p190(7%), t(9;22) BCR/ABL p210(14%), t(10;11) MLL/ AF10(7%),t(15;17) PML/RARA bcr-2(14%), t(8;21) AML/ETO(38%), KMT2A (MLL-PTD-9) (7%) и KMT2A (MLL-PTD-10) (7%) )присутствиемолекул ДНК,были данны соответствующие рекомендации.

Ўзбек

The article discusses molecular genetic studies of markers for the diagnosis of primary leukemia based on biochip technology. The study included 2,600 gene translocations of 250 patients diagnosed with acute leukemia. Of these, 13 (26%) had a chimeric gene (t(9;22) BCR/ABL p190(7%), t(9;22) BCR/ABL p210(14%), t(10;11) MLL/AF10(7%),t(15;17) PML/RARA bcr-2(14%), t(8;21) AML/ ETO(38%), KMT2A (MLL-PTD-9)(7%) and KMT2A (MLL-PTD-10) (7%)) presence of DNA molecules, the relevant recommendations were given.

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